Hemopoiesis in mouse heterozygous for the W trait. Difference in postirradiation recovery related to the defect in formation of transient endogenous spleen colonies.

Strahlentherapie Pub Date : 1985-07-01
W Wiktor-Jedrzejczak, E Urbanowska, C Szczylik, Z Pojda, M Siekierzynski
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Abstract

The hemopoietic regeneration following midlethal irradiation in Wv/+ mice had similarly biphasic kinetics as in their hematologically normal +/+ littermates. The first abortive phase of regeneration was either severely reduced (formation of transient endogenous spleen colonies, reticulocyte count, granulocyte count) or absent (spleen and femur cellularity, platelet count, PCV) in Wv/+ mice, when compared to +/+ mice. The second phase leading to permanent recovery of hemopoiesis was in Wv/+ mice delayed in time. Moreover, although to a lesser extent the values of spleen and femur cellularity, PCV and platelet count were decreased in Wv/+ mice. Postirradiation bleeding, which stimulated particularly the 1st phase of regeneration both in Wv/+ and +/+ mice did not lead to the minimization of differences between above two genotypes. It is suggested that the observed differences in the abortive regeneration between Wv/+ and +/+ mice are primarily dependent on the presence in Wv/+ mice of selective defect of transient endogenous colony forming units (TE-CFUs). Moreover, it is possible that the differences in the second phase of regeneration leading to permanent recovery are secondarily dependent on the TE-CFUs defect, as most probably the TE-CFU is the step in stem cell differentiation to mature cells.

小鼠造血系统中W性状的杂合。放疗后恢复的差异与瞬时内源性脾脏菌落形成缺陷有关。
中致死照射后Wv/+小鼠的造血再生与血液学正常的+/+幼崽具有相似的双相动力学。与+/+小鼠相比,Wv/+小鼠再生的第一个流产期要么严重减少(瞬时内源性脾脏菌落的形成、网织红细胞计数、粒细胞计数),要么缺失(脾脏和股骨细胞数量、血小板计数、PCV)。导致永久性造血功能恢复的第二阶段在Wv/+小鼠中延迟出现。此外,尽管Wv/+小鼠的脾脏和股骨细胞量、PCV和血小板计数在较小程度上降低。放疗后出血,尤其是刺激Wv/+和+/+小鼠再生的第一阶段,并没有导致上述两种基因型之间差异的最小化。我们认为Wv/+和+/+小鼠再生失败的差异主要取决于Wv/+小鼠中存在瞬时内源性集落形成单位(TE-CFUs)的选择性缺陷。此外,导致永久性恢复的再生第二阶段的差异可能其次依赖于TE-CFU缺陷,因为TE-CFU很可能是干细胞向成熟细胞分化的步骤。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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