Gastrointestinal aluminium absorption: is it modulated by the iron-absorptive mechanism?

Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress Pub Date : 1985-01-01

J B Cannata, C Suarez Suarez, V Cuesta, R Rodriguez Roza, M T Allende, J Herrera, J Perez Llanderal

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Abstract

Gastrointestinal aluminium (A1) absorption has been proved but its mechanism is still unknown. This study investigates the pattern of A1 absorption in patients with different degrees of iron stores. We studied 29 haemodialysis patients forming three groups according to their serum ferritin values. Over seven days all patients received the same dose of aluminium hydroxide after which patients with 'low-normal' and normal serum ferritin increased their serum A1 proportionally with the increased aluminium hydroxide intake. By contrast patients with high serum ferritin did not show any change in their serum A1 values. Our results therefore suggest that a 'common pathway' of metal absorption could be implicated in A1 absorption. Serum ferritin might be a valuable predictor of different behaviour.

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胃肠道铝吸收:是否受铁吸收机制的调节?

胃肠道铝(A1)的吸收已被证实，但其机制尚不清楚。本研究探讨了不同程度铁储备患者对A1的吸收模式。根据血液透析患者血清铁蛋白水平，将29例血液透析患者分为三组。在7天的时间里，所有患者都接受了相同剂量的氢氧化铝，之后，血清铁蛋白“低正常”和正常的患者的血清A1随着氢氧化铝摄入量的增加而成比例地增加。相比之下，高血清铁蛋白患者的血清A1值没有任何变化。因此，我们的结果表明，金属吸收的“共同途径”可能与A1吸收有关。血清铁蛋白可能是不同行为的一个有价值的预测指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress

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