Are beta-haemolytic streptococci involved in the pathogenesis of mesangial IgA-nephropathy?

Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress Pub Date : 1985-01-01

S Rekola, A Bergstrand, H Bucht, A Lindberg

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Abstract

In retrospect we have found that 38 of 187 patients who fulfilled the criteria of mesangial IgA-nephropathy had possible acute glomerulonephritis at the onset of their disease. We have therefore studied anti-streptococcal antibodies (ASO and ADNAseB) prospectively. Forty-three per cent of the patients had ADNAseB greater than 800 units. Thirty-one per cent of the patients studied more than once had a fourfold or greater change in their ADNAseB titre. Thirty-three per cent of the patients had different groups of beta-haemolytic streptococci isolated from their throats. This indicates a possible role of beta-haemolytic streptococci in the pathogenesis of some cases of mesangial IgA-nephropathy.

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溶血性链球菌参与系膜iga肾病的发病机制吗?

回顾过去，我们发现187例符合系膜iga肾病标准的患者中有38例在发病时可能患有急性肾小球肾炎。因此，我们对抗链球菌抗体(ASO和ADNAseB)进行了前瞻性研究。43%的患者ADNAseB大于800单位。31%的研究患者的ADNAseB滴度不止一次发生了4倍或更大的变化。33%的患者从他们的喉咙中分离出不同组的溶血链球菌。这表明β -溶血性链球菌可能在一些肾小球系膜iga肾病的发病机制中起作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress

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