Genetic linkage studies in ataxia-telangiectasia: Gm markers.

Abstract

Gm marker studies were performed on seven families with ataxia-telangiectasia in order to determine genetic linkage. For statistical analysis, the disorder was assumed to be monogenic. Using LOD scores computed by the program LIPED, tight linkage was excluded at a recombination fraction of less than or equal to 2 cM. This distance (equivalent to approximately two million nucleotides) includes most or all of the 14q32 chromosomal region.