[Prognostic factors during control of the course of lymphogranulomatosis: comparison of 2 therapy technics and analysis of serologic parameters].

Strahlentherapie Pub Date : 1985-04-01
U Schulz, U Malewski, W Alberti
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Abstract

Between 1970 and 1980, 339 patients with Hodgkin's disease in stages IA to IIIB were treated at the Department of Radiotherapy, University of Essen, FRG. 65 patients (group A) were irradiated using a multiple-field-technique with cobalt-60, 110 patients (group B) with mantle fields, inverted Y or paraaortic extended fields given with 5.7 MeV photons. There were no significant differences between the cumulative survival times, local and marginal recurrences. However, the recurrence rates of unirradiated lymph node regions were different, mainly due to absent or given paraaortic treatment. The presence of initially normal blood parameters (BSR, relatively lymphocyte count, haptoglobin, copper, iron) is of high prognostic value. Combined, they allow a correct prognosis as to the five year recurrence rate in up to 98% of cases. The prognostic precision of initially pathologic values was considerably reduced, even if a normalization had occurred after one year from the initiation of treatment.

[淋巴肉芽肿病病程控制中的预后因素:两种治疗方法的比较及血清学指标分析]。
1970年至1980年间,339名IA至IIIB期霍奇金病患者在德国埃森大学放射学系接受了治疗。65例患者(A组)采用钴-60多场辐照技术,110例患者(B组)采用地幔场、倒Y场或斜向扩展场,给予5.7 MeV光子。累积生存时间、局部复发和边缘复发之间无显著差异。然而,未放疗的淋巴结区复发率不同,主要是由于未放疗或给予了旁主动脉治疗。最初正常的血液参数(BSR,相对淋巴细胞计数,触珠蛋白,铜,铁)的存在具有很高的预后价值。综合起来,它们可以对高达98%的病例的5年复发率做出正确的预后。即使在开始治疗一年后出现正常化,最初病理值的预后精度也大大降低。
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