Curved DNA.

E N Trifonov
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引用次数: 0

Abstract

A priori considerations and the concept of the sequence-dependent local curving of the DNA axis. Experimental evidence: electric dichroism (relaxation time measurements); anomalous electrophoretic mobility and gel-filtration of some restriction fragments of DNA; one-sided binding of the nucleosomal DNA to the mica surface. Theoretical predictions concerning the nucleotide sequences of the curved DNA. Discovery of the dinucleotide periodicity in the chromatin DNA. The sequence periodicity as a tool for mapping of the nucleosomes along the sequences. Preferential binding of the histone octamers to the curved pieces of DNA--sequence analysis predictions and comparison with experiments: Theoretical and experimental estimates of the tilt and roll angles for different combinations of the neighboring base-pairs. Inherent sequence-dependent curvature and apparent persistence length of DNA.

弯曲的DNA。
先验的考虑和DNA轴的序列依赖的局部曲线的概念。实验证据:电二色性(弛豫时间测量);某些DNA限制性片段的异常电泳迁移率和凝胶过滤;核小体DNA与云母表面的单侧结合。关于弯曲DNA的核苷酸序列的理论预测。染色质DNA中二核苷酸周期性的发现。序列周期性作为沿序列绘制核小体的工具。组蛋白八聚体与DNA弯曲片段的优先结合-序列分析预测和与实验的比较:对相邻碱基对不同组合的倾斜和滚动角度的理论和实验估计。DNA固有的序列依赖曲率和表观持续长度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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