Prostacyclin-synthesis stimulating plasma factor and platelet sensitivity in preeclampsia.

Abstract

Hemostatic regulation is partly maintained by antiaggregatory and vasodilative prostaglandins (PGI2, PGE1, PGD2) and by the proaggregatory and vasoconstrictive Thromboxane A2. PGI2-Synthesis is regulated by a plasma factor (PF). This plasma factor and the platelet sensitivity (PS) to PGI2 and PGE1 decrease during pregnancy towards term. In preeclampsia PF and PS is more decreased than in healthy pregnant women. Both parameters increase significantly after delivery. The decreased values of PF and PS in preeclampsia demonstrate a dysregulation of hemostasis in preeclampsia.