Comparison of three immunosuppressive regimens in kidney transplantation: a single-centre randomised study.

Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress Pub Date : 1985-01-01

M Hourmant, J P Soulillou, J Guenel

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Abstract

Three immunosuppressive regimens have been compared: conventional treatment including anti-thymocyte globulin (ATG) (32 patients) with cyclosporine (Cys) alone (21 patients), sequential combination of ATG with Cys (35 patients). Actuarial graft survivals were: ATG 73 per cent, Cys alone 88 per cent at nine months and ATG/Cys 92 per cent at one to two years. Transplant function was significantly worse with Cys as initial treatment compared with that in controls, while it was similar with ATG/Cys. The Cys dose used was low and no severe infection nor immunoglobulin abnormalities were noticed. Corticosteroids were withdrawn with both Cys protocols, except for rejection treatment.

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肾移植中三种免疫抑制方案的比较:一项单中心随机研究。

比较了三种免疫抑制方案:常规治疗包括抗胸腺细胞球蛋白(ATG)(32例)和单独环孢素(Cys)(21例)，ATG与Cys序贯联合(35例)。精算移植存活率为:ATG 73%， 9个月时仅Cys 88%， 1至2年时ATG/Cys 92%。与对照组相比，初始治疗Cys组移植功能明显差，而与ATG/Cys组相似。使用的Cys剂量低，未发现严重感染和免疫球蛋白异常。除排斥反应治疗外，两种Cys方案均停用皮质类固醇。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress

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