Does renal failure induce a decrease in cyclosporine blood concentrations?

Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress Pub Date : 1985-01-01

M Burnier, P Aebischer, J P Wauters, J L Schelling

引用次数: 0

Abstract

Blood Cys concentrations were monitored twice weekly by RIA in nine patients undergoing renal transplantation. The Cys dose was adapted to obtain blood values between 100-400ng/ml. A negative correlation was found between plasma creatinine and blood Cys, even in those patients in whom the oral dosage was not changed (r = 0.65, n = 23, p less than 0.001). In vitro studies showed no effect of uraemic blood on Cys measurement. It seems probable that uraemia induces changes in distribution volume and/or gastrointestinal absorption of the drug. Careful monitoring of Cys during uraemia is therefore warranted.

本刊更多论文

肾功能衰竭会导致环孢素血药浓度下降吗?

对9例肾移植患者进行每周一两次的血Cys浓度监测。Cys剂量适用于100-400ng/ml的血药浓度。血浆肌酐与血Cys呈负相关，即使在口服剂量不变的患者中也是如此(r = 0.65, n = 23, p < 0.001)。体外研究表明，尿毒症血液对Cys测量没有影响。尿毒症似乎可能引起药物分布、体积和/或胃肠道吸收的改变。因此，有必要在尿毒症期间仔细监测Cys。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress

自引率

0.00%

发文量