Unilateral involvement of kidneys in mice infected with Candida albicans.

Abstract

Mice injected with 10(3) cells of a virulent isolate of Candida albicans via the lateral tail vein developed frequent unilateral abnormalities of the right but not the left kidneys. Initially the number of colony forming units in the right and left kidneys were similar but the number of colonies became consistently higher in the right kidneys as the infection progressed. The frequency of unilateral involvement decreased when the inoculum size was increased to 5 X 10(3) cells. These observations indicate that when growth of C. albicans in vivo is monitored over a period of time starting with a low inoculum, it is critical to be consistent in culturing kidneys from the same side.