{"title":"Interaction of anthracycline drugs with canine and bovine carrier erythrocytes.","authors":"J R DeLoach, R Droleskey","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Daunomycin interacts with canine and bovine erythrocytes making them permeable to [14C]sucrose, a nonpermeant. The drug causes the red blood cell (RBC) to swell and form an echinocyte-stomatocyte cell type. Defects in the RBC membrane were observed for murine RBC as well. Thus, daunomycin interacts with RBC such that its deleterious action would not make this drug a promising candidate for encapsulation in carrier erythrocytes. Contrary to previous reports, daunomycin easily permeates murine RBC and avidly binds to the cells; as much as 70% of the drug remains associated with normal murine RBC. Several different approaches were taken to unequivocally establish that daunomycin does not entrap in canine RBC in a classical manner. The extent of interaction of the drug with RBC does not appear to be RBC specific because similar results were obtained with canine, bovine, and murine RBC.</p>","PeriodicalId":14978,"journal":{"name":"Journal of applied biochemistry","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1985-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of applied biochemistry","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Daunomycin interacts with canine and bovine erythrocytes making them permeable to [14C]sucrose, a nonpermeant. The drug causes the red blood cell (RBC) to swell and form an echinocyte-stomatocyte cell type. Defects in the RBC membrane were observed for murine RBC as well. Thus, daunomycin interacts with RBC such that its deleterious action would not make this drug a promising candidate for encapsulation in carrier erythrocytes. Contrary to previous reports, daunomycin easily permeates murine RBC and avidly binds to the cells; as much as 70% of the drug remains associated with normal murine RBC. Several different approaches were taken to unequivocally establish that daunomycin does not entrap in canine RBC in a classical manner. The extent of interaction of the drug with RBC does not appear to be RBC specific because similar results were obtained with canine, bovine, and murine RBC.
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