Causal associations between gut microbiota and autism spectrum disorder and attention-deficit/hyperactivity disorder: a two-sample mendelian randomization study.

IF 3 3区生物学 Q2 GENETICS & HEREDITY

Frontiers in Genetics Pub Date : 2026-10-16 eCollection Date: 2026-01-01 DOI:10.3389/fgene.2026.1972696

Shangyun Shi, Ancha Baranova, Hongbao Cao, Fuquan Zhang

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引用次数: 0

Abstract

Background: The gut microbiota have been implicated in the development of autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD). However, the precise causal relationships between the gut microbiota and ASD or ADHD remain unclear.

Methods: We investigated potential causal associations between gut microbiota and two neurodevelopmental mental disorders (ASD and ADHD) via Mendelian randomization (MR) analyses. We used genome-wide association study (GWAS) summary datasets, including data from the MiBioGen consortium (N = 18,340), the Dutch Microbiome Project (N = 8,208), an ASD GWAS (N = 46,350), and an ADHD GWAS (N = 292,548).

Results: Our MR analysis identified 16 gut bacterial taxa associated with ASD. Seven taxa were associated with an increased risk (OR 1.03-1.10), while nine were associated with a decreased risk (OR 0.89-0.96). Conversely, 28 gut bacterial taxa were causally linked to ADHD: 16 were associated with an increased risk (OR 1.02-1.04), and 12 were associated with a decreased risk (OR 0.95-0.98). Both ASD and ADHD were causally influenced by the family "Clostridiales noname," but with opposite effects.

Conclusion: Our MR analysis revealed causal effects of specific gut microbiota on ASD and ADHD, suggesting that certain gut microbes may play a role in the development and treatment of these disorders, as well as in their differential diagnosis.

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肠道微生物群与自闭症谱系障碍和注意力缺陷/多动障碍之间的因果关系：一项双样本孟德尔随机化研究。

背景：肠道微生物群与自闭症谱系障碍（ASD）和注意力缺陷/多动障碍（ADHD）的发展有关。然而，肠道微生物群与ASD或ADHD之间的确切因果关系尚不清楚。方法：我们通过孟德尔随机化（MR）分析调查肠道微生物群与两种神经发育性精神障碍（ASD和ADHD）之间的潜在因果关系。我们使用全基因组关联研究（GWAS）汇总数据集，包括来自MiBioGen联盟（N = 18,340）、荷兰微生物组计划（N = 8,208）、ASD GWAS （N = 46,350）和ADHD GWAS （N = 292,548）的数据。结果：我们的MR分析鉴定了16个与ASD相关的肠道细菌分类群。7个类群与风险增加相关（OR 1.03-1.10）， 9个类群与风险降低相关（OR 0.89-0.96）。相反，28个肠道细菌分类群与ADHD有因果关系：16个与风险增加相关（OR 1.02-1.04）， 12个与风险降低相关（OR 0.95-0.98）。ASD和ADHD都受到“梭状芽孢杆菌家族”的因果影响，但效果相反。结论：我们的MR分析揭示了特定肠道微生物群对ASD和ADHD的因果影响，表明某些肠道微生物可能在这些疾病的发展和治疗中发挥作用，以及它们的鉴别诊断。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Genetics Biochemistry, Genetics and Molecular Biology-Molecular Medicine

CiteScore

5.50

自引率

8.10%

发文量

3491

审稿时长

14 weeks

期刊介绍： Frontiers in Genetics publishes rigorously peer-reviewed research on genes and genomes relating to all the domains of life, from humans to plants to livestock and other model organisms. Led by an outstanding Editorial Board of the world’s leading experts, this multidisciplinary, open-access journal is at the forefront of communicating cutting-edge research to researchers, academics, clinicians, policy makers and the public. The study of inheritance and the impact of the genome on various biological processes is well documented. However, the majority of discoveries are still to come. A new era is seeing major developments in the function and variability of the genome, the use of genetic and genomic tools and the analysis of the genetic basis of various biological phenomena.