Assessment of the Appropriateness of Drug Prophylaxis for One-Day Chemotherapy-Induced Nausea and Vomiting: A Multicenter Study in China

IF 1.1 4区医学 Q3 PHARMACOLOGY & PHARMACY

Journal of Clinical Pharmacy and Therapeutics Pub Date : 2026-10-25 DOI:10.1155/jcpt/9954153

Jiawei Song, Xiaoqian Liu, Jingyu Xu, Long Wang, Jie Fan, Yuanyuan Wang

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Abstract

Objective

To assess the appropriateness of antiemetic prophylaxis for one-day chemotherapy-induced nausea and vomiting (CINV), aiming to provide a reference for optimizing CINV drug prophylaxis practices.

Methods

A multicenter retrospective study was conducted, including a total of 643 cases of CINV prophylaxis from five Grade A tertiary comprehensive hospitals in Anhui Province, China, between January and June 2024. The appropriateness of the instances was comprehensively scored using the attribute hierarchical model (AHM) method, based on established criteria for evaluating the appropriateness of CINV prophylaxis.

Results

The mean score for all cases was 78.65 ± 11.98. Of these, 165 cases (25.66%) scored ≥ 90, 137 cases (21.31%) scored 80 to < 90, 304 cases (47.28%) scored 60 to < 80, and 37 cases (5.75%) scored < 60. The main inappropriateness of prescribing identified was as follows: the prophylactic regimen was not recommended by guidelines (441 cases, 68.58%); the prophylactic regimen was not selected according to the emetogenic risk of chemotherapy drugs (314 cases, 48.83%); the duration of prophylaxis was unreasonable (268 cases, 41.68%); the dosage was inappropriate (178 cases, 27.68%); and the timing of administration was not suitable (156 cases, 24.26%).

Conclusion

The guideline-recommended one-day intravenous chemotherapy regimens demonstrate poor adherence, and a considerable number of inappropriate prescribing practices were observed in the prophylactic drug regimens used for one-day intravenous chemotherapy. The inappropriateness of CINV drug prophylaxis is relatively concentrated, and targeted interventions are needed to improve the appropriateness of CINV prophylaxis prescribing.

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1天化疗引起的恶心和呕吐的药物预防适宜性评估：中国的一项多中心研究

目的评价1天化疗引起的恶心呕吐（CINV）预防止吐的适宜性，为优化CINV药物预防措施提供参考。方法采用多中心回顾性研究方法，选取安徽省5家三级甲等综合医院2024年1 - 6月接受CINV预防治疗的643例患者。根据已建立的评估CINV预防适宜性的标准，使用属性层次模型（AHM）方法对实例的适宜性进行综合评分。结果所有病例的平均评分为78.65±11.98。其中≥90分165例（25.66%），80 ~ 90分137例（21.31%），60 ~ 80分304例（47.28%），60分37例（5.75%）。处方不适宜性主要为：未按指南推荐预防方案（441例，占68.58%）；未根据化疗药物致吐风险选择预防方案（314例，48.83%）；预防用药时间不合理（268例，41.68%）；用药剂量不适宜（178例，27.68%）；给药时机不合适（156例，24.26%）。结论指南推荐的1天静脉化疗方案依从性较差，在1天静脉化疗预防性用药方案中存在相当多的不当处方操作。CINV药物预防的不适宜性较为集中，需要有针对性的干预措施来提高CINV预防处方的适宜性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Pharmacy and Therapeutics 医学-药学

CiteScore

4.10

自引率

5.00%

发文量

226

审稿时长

6 months

期刊介绍： The Journal of Clinical Pharmacy and Therapeutics provides a forum for clinicians, pharmacists and pharmacologists to explore and report on issues of common interest. Reports and commentaries on current issues in medical and pharmaceutical practice are encouraged. Papers on evidence-based clinical practice and multidisciplinary collaborative work are particularly welcome. Regular sections in the journal include: editorials, commentaries, reviews (including systematic overviews and meta-analyses), original research and reports, and book reviews. Its scope embraces all aspects of clinical drug development and therapeutics, including: Rational therapeutics Evidence-based practice Safety, cost-effectiveness and clinical efficacy of drugs Drug interactions Clinical impact of drug formulations Pharmacogenetics Personalised, stratified and translational medicine Clinical pharmacokinetics.