{"title":"Contemporary issues relating to calcium pyrophosphate deposition disease.","authors":"Sara K Tedeschi","doi":"10.1093/rheumatology/keag588","DOIUrl":null,"url":null,"abstract":"<p><p>Calcium pyrophosphate deposition (CPPD) disease is a common crystalline arthritis that has historically been under-studied compared to other rheumatic diseases including gout. For decades, the presence of CPPD in joints has been consider of uncertain clinical importance, with conflicting reports on whether CPPD leads to osteoarthritis progression or other adverse outcomes. A growing body of literature in the past five years has challenged the prevailing view of CPPD disease as \"just chondrocalcinosis.\" These findings have arrived together with recent developments in classifying CPPD disease for research studies, advances in quantification of CPPD on imaging studies, consensus on outcomes to be measured in CPPD disease clinical trials, newly-identified genetic associations, and updates in the nomenclature for this crystalline arthritis. This review summarizes key updates in each of these realms.</p>","PeriodicalId":21255,"journal":{"name":"Rheumatology","volume":" ","pages":""},"PeriodicalIF":4.7000,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13690184/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Rheumatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/rheumatology/keag588","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RHEUMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Calcium pyrophosphate deposition (CPPD) disease is a common crystalline arthritis that has historically been under-studied compared to other rheumatic diseases including gout. For decades, the presence of CPPD in joints has been consider of uncertain clinical importance, with conflicting reports on whether CPPD leads to osteoarthritis progression or other adverse outcomes. A growing body of literature in the past five years has challenged the prevailing view of CPPD disease as "just chondrocalcinosis." These findings have arrived together with recent developments in classifying CPPD disease for research studies, advances in quantification of CPPD on imaging studies, consensus on outcomes to be measured in CPPD disease clinical trials, newly-identified genetic associations, and updates in the nomenclature for this crystalline arthritis. This review summarizes key updates in each of these realms.
期刊介绍：
Rheumatology strives to support research and discovery by publishing the highest quality original scientific papers with a focus on basic, clinical and translational research. The journal’s subject areas cover a wide range of paediatric and adult rheumatological conditions from an international perspective. It is an official journal of the British Society for Rheumatology, published by Oxford University Press.
Rheumatology publishes original articles, reviews, editorials, guidelines, concise reports, meta-analyses, original case reports, clinical vignettes, letters and matters arising from published material. The journal takes pride in serving the global rheumatology community, with a focus on high societal impact in the form of podcasts, videos and extended social media presence, and utilizing metrics such as Altmetric. Keep up to date by following the journal on Twitter @RheumJnl.
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