A New Frontier: Partial Cellular Reprogramming in Plastic Surgery.

IF 3.6 2区医学 Q1 SURGERY

Plastic and reconstructive surgery Pub Date : 2026-10-20 DOI:10.1097/PRS.0000000000013549

Amir-Ala Mahmoud, Arman Fijany, Libby Copeland-Halperin, Granger Wong

引用次数: 0

Abstract

Partial cellular reprogramming employs Yamanaka factors to shift aging cells toward a younger epigenetic state without compromising cellular identity. Over two decades, this Nobel Prize winning breakthrough has advanced from the bench to a first in-human trial in 2026 for optic neuropathy and glaucoma. Here, we outline the foundation of partial cellular reprogramming and delineate its intersection with our field. Defined by innovation, plastic surgery can shape how partial reprogramming is applied in what may prove to be a transformative chapter for our specialty.

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新前沿：整形外科中的部分细胞重编程。

部分细胞重编程利用山中因子将衰老细胞转变为年轻的表观遗传状态，而不损害细胞身份。20多年来，这项获得诺贝尔奖的突破已经从实验室发展到2026年的第一次人体试验，用于治疗视神经病变和青光眼。在这里，我们概述了部分细胞重编程的基础，并描绘了它与我们的领域的交集。由创新定义，整形外科可以塑造部分重编程的应用，这可能被证明是我们专业的变革篇章。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Plastic and reconstructive surgery 医学-外科

CiteScore

5.00

自引率

13.90%

发文量

1436

审稿时长

1.5 months

期刊介绍： For more than 70 years Plastic and Reconstructive Surgery® has been the one consistently excellent reference for every specialist who uses plastic surgery techniques or works in conjunction with a plastic surgeon. Plastic and Reconstructive Surgery® , the official journal of the American Society of Plastic Surgeons, is a benefit of Society membership, and is also available on a subscription basis. Plastic and Reconstructive Surgery® brings subscribers up-to-the-minute reports on the latest techniques and follow-up for all areas of plastic and reconstructive surgery, including breast reconstruction, experimental studies, maxillofacial reconstruction, hand and microsurgery, burn repair, cosmetic surgery, as well as news on medicolegal issues. The cosmetic section provides expanded coverage on new procedures and techniques and offers more cosmetic-specific content than any other journal. All subscribers enjoy full access to the Journal''s website, which features broadcast quality videos of reconstructive and cosmetic procedures, podcasts, comprehensive article archives dating to 1946, and additional benefits offered by the newly-redesigned website.