¹⁸F-FDG PET/CT and post-treatment lung function in adolescent tuberculosis.

IF 4.4 3区医学 Q1 RESPIRATORY SYSTEM

ERJ Open Research Pub Date : 2026-10-19 eCollection Date: 2026-09-01 DOI:10.1183/23120541.00484-2026

Alex G G Doruyter, Elizna Maasdorp, Marieke M van der Zalm, Andriëtte M Hiemstra, Megan Palmer, Stephanus T Malherbe, James A Seddon

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引用次数: 0

Abstract

Background: Data on post-tuberculosis outcomes in adolescents are scarce. Although fluorine-18 fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography/computed tomography (PET/CT) has been used in adult tuberculosis research, little is known about the association between PET/CT findings and functional outcomes in general.

Methods: Early FDG PET/CT images of 50 adolescents (31 female, median age 17.2 years) with confirmed pulmonary tuberculosis were read visually and quantitative data of disease burden (total lung volume, cavity volume, total hard volume and total glycolytic activity (TGA)) were extracted and tested for associations with clinical risk factors and spirometry measures after treatment completion.

Findings: Involvement of three or more lobes was present in 66% of adolescents, with consolidation in 84%, nodules in 92% and cavities in 84%. Comparatively, smokers had lower TGA values (p=0.034). Larger cavity volume was the strongest predictor of reduced forced expiratory volume in 1 s (FEV₁) and forced vital capacity (FVC) post treatment (β=-1.78- -0.87; p=0.0024-0.047). Corrected total hard volume and corrected TGA were associated with FEV₁ and FVC z-scores, although no individual predictor coefficients survived correction for multiple comparisons.

Interpretation: PET/CT features in this adolescent cohort matched patterns described in adults and were frequently severe. Radiological severity measures were associated with poorer spirometry after treatment. More data, including longitudinal imaging and functional outcomes, are required to better understand pathophysiology in this age group.

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18F-FDG PET/CT与治疗后青少年肺结核肺功能的关系。

背景：关于青少年结核病后预后的数据很少。尽管氟-18氟脱氧葡萄糖（18F-FDG）正电子发射断层扫描/计算机断层扫描（PET/CT）已被用于成人结核病研究，但人们对PET/CT结果与功能预后之间的关系知之甚少。方法：对50例确诊为肺结核的青少年（女性31例，中位年龄17.2岁）的早期FDG PET/CT图像进行直观读取，提取疾病负担的定量数据（肺总容积、腔容积、总硬容积和总糖溶酶活性（TGA）），并检测其与临床危险因素和治疗结束后肺活量测定的相关性。结果：66%的青少年有三个或更多肺叶受累，84%为实变，92%为结节，84%为空腔。相比之下，吸烟者的TGA值更低（p=0.034）。较大的腔容积是治疗后1 s用力呼气量（FEV1）和用力肺活量（FVC）减少的最强预测因子（β=-1.78 ~ -0.87; p=0.0024 ~ 0.047）。校正后的总硬体积和校正后的TGA与FEV1和FVC z分数相关，尽管没有个体预测系数在多次比较校正后存活下来。解释：该青少年队列的PET/CT特征与成人描述的模式相匹配，并且通常很严重。放射学严重性测量与治疗后较差的肺活量有关。需要更多的数据，包括纵向成像和功能结果，以更好地了解该年龄组的病理生理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ERJ Open Research Medicine-Pulmonary and Respiratory Medicine

CiteScore

6.20

自引率

4.30%

发文量

273

审稿时长

8 weeks

期刊介绍： ERJ Open Research is a fully open access original research journal, published online by the European Respiratory Society. The journal aims to publish high-quality work in all fields of respiratory science and medicine, covering basic science, clinical translational science and clinical medicine. The journal was created to help fulfil the ERS objective to disseminate scientific and educational material to its members and to the medical community, but also to provide researchers with an affordable open access specialty journal in which to publish their work.