Factors associated with serum GDF-15, iron deficiency and lower hemoglobin levels in patients with chronic heart failure and healthy elderly people.

IF 1.5 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Heart and Vessels Pub Date : 2026-10-20 DOI:10.1007/s00380-026-02775-z

Taira Fukuda, Seiko Tokoi, Riichi Nishikawa, Takaaki Hasegawa, Kan Kondo, Ryo Kayashima, Kaori Kono, Shu Inami, Hirohisa Amano, Takuo Arikawa, Hiroshi Yagi, Suomi Yamaguchi, Masashi Sakuma, Shigeru Toyoda, Toshiaki Nakajima

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引用次数: 0

Abstract

Background: Coexistent chronic heart failure and iron deficiency is frequently encountered in clinical practice and affects prognosis. We investigated factors associated with serum growth differentiation factor (GDF)-15, iron deficiency and lower hemoglobin levels in patients with heart failure and healthy elderly individuals.

Methods and results: Blood tests were performed on 90 patients with heart failure (aged 75.0 ± 10.7 years) and 73 healthy elderly individuals (aged 76.3 ± 6.4 years). Serum GDF-15, tumor necrosis factor (TNF) α, N-terminal pro-brain natriuretic peptide (NT-proBNP), and hepcidin concentrations were measured using enzyme-linked immunosorbent assay. Left atrial volume index (LAVI) was measured by echocardiography. Hemoglobin (Hb) in healthy elderly individuals correlated with serum iron and hepcidin. In contrast, Hb in patients with heart failure correlated with serum iron and GDF-15. Serum GDF-15 concentration in healthy elderly subjects correlated with estimated glomerular filtration rate, serum iron, and hepcidin. In contrast, in patients with heart failure, it correlated with NT-proBNP and TNFα. In patients with heart failure, serum iron correlated with LAVI.

Conclusions: Lower hemoglobin levels in patients with heart failure might be associated with elevated serum GDF-15 due to higher serum NT-proBNP and inflammation, as well as iron deficiency. In contrast, lower hemoglobin levels in healthy elderly individuals might involve lower serum iron and hepcidin levels. Lower serum iron concentration was suggested to be involved in left atrial remodeling in patients with heart failure.

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慢性心力衰竭患者和健康老年人血清GDF-15、缺铁和血红蛋白水平降低的相关因素

背景：慢性心力衰竭合并缺铁是临床上常见的影响预后的疾病。我们研究了心力衰竭患者和健康老年人血清生长分化因子(GDF)-15、缺铁和血红蛋白水平降低的相关因素。方法与结果：对90例心力衰竭患者（75.0±10.7岁）和73例健康老年人（76.3±6.4岁）进行血液检查。采用酶联免疫吸附法测定血清GDF-15、肿瘤坏死因子(TNF) α、n端前脑利钠肽（NT-proBNP）和hepcidin浓度。超声心动图测量左房容积指数（LAVI）。健康老年人血红蛋白（Hb）与血清铁和hepcidin相关。相反，心力衰竭患者的Hb与血清铁和GDF-15相关。健康老年人血清GDF-15浓度与肾小球滤过率、血清铁和hepcidin相关。相反，在心力衰竭患者中，它与NT-proBNP和TNFα相关。在心力衰竭患者中，血清铁与LAVI相关。结论：心力衰竭患者较低的血红蛋白水平可能与血清GDF-15升高有关，这是由于血清NT-proBNP升高、炎症以及缺铁所致。相反，健康老年人较低的血红蛋白水平可能与较低的血清铁和肝磷脂水平有关。低血清铁浓度可能与心力衰竭患者左房重构有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Heart and Vessels 医学-外周血管病

CiteScore

3.10

自引率

13.30%

发文量

211

审稿时长

2 months

期刊介绍： Heart and Vessels is an English-language journal that provides a forum of original ideas, excellent methods, and fascinating techniques on cardiovascular disease fields. All papers submitted for publication are evaluated only with regard to scientific quality and relevance to the heart and vessels. Contributions from those engaged in practical medicine, as well as from those involved in basic research, are welcomed.