Functional role of the second messengers PtdIns(3,4,5)P₃ and PtdIns(3,4)P₂ in carcinogenesis.

IF 2.5 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biological Chemistry Pub Date : 2026-10-20 DOI:10.1515/hsz-2026-0181

Nina Nelson, Manfred Jücker

引用次数: 0

Abstract

PtdIns(3,4,5)P₃ and PtdIns(3,4)P₂ are second messengers and key regulators of tumorigenesis. Their production and degradation are spatiotemporally regulated by a network of phosphoinositide kinases and phosphatases which is frequently altered in cancer. Both molecules serve as docking and activation sites for PH-domain containing effector proteins regulating oncogenic traits. This review will detail the proteins and pathways involved in the upstream regulation and downstream functions of PtdIns(3,4,5)P₃ and PtdIns(3,4)P₂. In addition, it will cover the spatiotemporal distribution of these two PtdIns and relevant analysis techniques.

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第二信使PtdIns(3,4,5)P3和PtdIns(3,4)P2在癌变中的功能作用。

PtdIns(3,4,5)P3和PtdIns(3,4)P2是肿瘤发生的第二信使和关键调节因子。它们的产生和降解在时空上受到磷酸肌苷激酶和磷酸酶网络的调节，这在癌症中经常发生改变。这两种分子都是调节致癌性状的ph结构域效应蛋白的对接和激活位点。本文将详细介绍PtdIns(3,4,5)P3和PtdIns(3,4)P2的上游调控和下游功能所涉及的蛋白质和途径。此外，还将介绍这两种ptdin的时空分布及其分析技术。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biological Chemistry 生物-生化与分子生物学

CiteScore

7.20

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Biological Chemistry keeps you up-to-date with all new developments in the molecular life sciences. In addition to original research reports, authoritative reviews written by leading researchers in the field keep you informed about the latest advances in the molecular life sciences. Rapid, yet rigorous reviewing ensures fast access to recent research results of exceptional significance in the biological sciences. Papers are published in a "Just Accepted" format within approx.72 hours of acceptance.

Functional role of the second messengers PtdIns(3,4,5)P3 and PtdIns(3,4)P2 in carcinogenesis.

Abstract

Functional role of the second messengers PtdIns(3,4,5)P₃ and PtdIns(3,4)P₂ in carcinogenesis.