{"title":"Chemically Induced Proximity in Biological Modulation","authors":"Xiaokang Jin, Chen Zhou, Xiaoyu Zhang","doi":"10.1021/acsbiomedchemau.6c00121","DOIUrl":null,"url":null,"abstract":"<p>Proximity is a fundamental prerequisite for a diverse\r\nrange of\r\nbiological processes. Chemically induced proximity strategies exploit\r\nthis principle to achieve the controllable modulation of targets of\r\ninterest through programmable biomolecular interactions. By rewiring\r\nbiological interactions, induced-proximity technologies can regulate\r\nprotein stability, activity, localization, transcription, and signaling.\r\nRecent advances have greatly expanded the repertoire of recruitable\r\neffector proteins, enabling the manipulation of challenging targets\r\npreviously considered intractable. In this review, we summarize the\r\nconceptual evolution and mechanistic diversity of induced-proximity\r\ntechnologies, highlighting platforms for targeted protein degradation,\r\nstabilization, post-translational modification editing, protein relocalization,\r\nand transcriptional control.</p>","PeriodicalId":29802,"journal":{"name":"ACS Bio & Med Chem Au","volume":"6 5","pages":"560–578"},"PeriodicalIF":3.5000,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Bio & Med Chem Au","FirstCategoryId":"1085","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acsbiomedchemau.6c00121","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/8/24 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Proximity is a fundamental prerequisite for a diverse
range of
biological processes. Chemically induced proximity strategies exploit
this principle to achieve the controllable modulation of targets of
interest through programmable biomolecular interactions. By rewiring
biological interactions, induced-proximity technologies can regulate
protein stability, activity, localization, transcription, and signaling.
Recent advances have greatly expanded the repertoire of recruitable
effector proteins, enabling the manipulation of challenging targets
previously considered intractable. In this review, we summarize the
conceptual evolution and mechanistic diversity of induced-proximity
technologies, highlighting platforms for targeted protein degradation,
stabilization, post-translational modification editing, protein relocalization,
and transcriptional control.
期刊介绍：
ACS Bio & Med Chem Au is a broad scope open access journal which publishes short letters comprehensive articles reviews and perspectives in all aspects of biological and medicinal chemistry. Studies providing fundamental insights or describing novel syntheses as well as clinical or other applications-based work are welcomed.This broad scope includes experimental and theoretical studies on the chemical physical mechanistic and/or structural basis of biological or cell function in all domains of life. It encompasses the fields of chemical biology synthetic biology disease biology cell biology agriculture and food natural products research nucleic acid biology neuroscience structural biology and biophysics.The journal publishes studies that pertain to a broad range of medicinal chemistry including compound design and optimization biological evaluation molecular mechanistic understanding of drug delivery and drug delivery systems imaging agents and pharmacology and translational science of both small and large bioactive molecules. Novel computational cheminformatics and structural studies for the identification (or structure-activity relationship analysis) of bioactive molecules ligands and their targets are also welcome. The journal will consider computational studies applying established computational methods but only in combination with novel and original experimental data (e.g. in cases where new compounds have been designed and tested).Also included in the scope of the journal are articles relating to infectious diseases research on pathogens host-pathogen interactions therapeutics diagnostics vaccines drug-delivery systems and other biomedical technology development pertaining to infectious diseases.
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