Dialkylation of Vinyl Arenes under Cobalt Catalysis

IF 4.7 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2026-10-15 DOI:10.1021/acs.orglett.6c03848

Jiabin Zhang,Yixuan Zhao,Dian Peng,Xiaonuo Shi,Shulei Ge,Qian Zhang,Jie Li

引用次数: 0

Abstract

Abstract Herein, a directing group and ligand-free cobalt-catalyzed alkene dialkylation with various alkyl halides and alkylzinc pivalates is reported. This method is distinguished by its broad scope, synthetic simplicity, and excellent regio- and chemoselectivities, thus providing a modular platform for the rapid synthesis of C(sp3)-rich carbogenic skeletons via 2-fold C(sp3)–C(sp3)/C(sp3)–C(sp3) bond formation. Moreover, the controllable transformations with those polyhaloalkanes, such as simple C1 synthons of CF2Br2, CCl4, or CBr4, as well as their derivatives are of special interest, which should find potential applications in both synthetic and medicinal chemistry.

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钴催化下乙烯基芳烃的二烷基化反应

摘要本文报道了一种定向基和无配体的钴催化烯烃与各种卤化烷基和烷基戊酸锌的二烷基化反应。该方法适用范围广，合成简单，具有良好的区域选择性和化学选择性，为通过2倍C(sp3)- C(sp3)/C(sp3) - C（sp3）键形成快速合成富含C（sp3）的碳骨架提供了模块化平台。此外，这些多卤代烷烃的可控转化，如CF2Br2、CCl4或CBr4的简单C1合成子及其衍生物，在合成和药物化学中都有潜在的应用前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.