Synthesis of Trifluoromethylphosphines from Alkylphosphines

IF 4.7 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2026-10-15 DOI:10.1021/acs.orglett.6c03969

Yingfan Yang,Jinwei Zhang,Longhui Chen,Guangwei Wang,Hongtai Chen

引用次数: 0

Abstract

Abstract Despite their value as unique ligands, synthesizing trifluoromethylphosphines (TFMPhos) traditionally requires reactive precursors (bearing P–H, P–X, or P–Si bonds). Directly converting a P–C(sp3) into a P–CF3 bond remains a formidable challenge. Herein, we report a practical, transition-metal-free method for the direct conversion of alkylphosphines into TFMPhos using Togni’s reagent II and NaI. This operationally simple, mild protocol features broad functional group tolerance, providing versatile access to diverse TFMPhos derivatives.

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由烷基膦合成三氟甲基膦

尽管它们作为独特的配体具有价值，但合成三氟甲基膦（TFMPhos）传统上需要活性前体（带有P-H， P-X或P-Si键）。将P-C （sp3）直接转化为P-CF3键仍然是一个艰巨的挑战。本文报道了一种实用的、无过渡金属的方法，利用Togni试剂II和NaI将烷基膦直接转化为TFMPhos。这种操作简单，温和的协议具有广泛的功能群容忍度，提供了多种TFMPhos衍生物的通用访问。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.