{"title":"Association between the total dosage of gonadotropin-releasing hormone antagonist during controlled ovarian stimulation and pregnancy outcomes.","authors":"Fen Tian, Bin Xu, Yanping Li, Jing Zhao","doi":"10.1530/RAF-26-0049","DOIUrl":null,"url":null,"abstract":"<p><strong>Lay summary: </strong>Gonadotropin-releasing hormone antagonist (GnRH-ant) protocols are widely used for ovarian stimulation in fertility treatments, such as in vitro fertilization. Some research suggested GnRH-ant might affect endometrial receptivity. This could reduce the chances of embryo implantation and pregnancy. Our study included 3,764 women undergoing embryo transfer using the GnRH-ant protocol. Women were grouped by the total GnRH-ant dose they received. We compared implantation, pregnancy, and miscarriage rates across the groups. We found that pregnancy outcomes were similar regardless of the total dose used. Also, higher doses did not reduce the chances of pregnancy after embryo transfer. This suggests doctors can adjust the dose based on each patient's needs without lowering the chance of success.</p>","PeriodicalId":101312,"journal":{"name":"Reproduction & fertility","volume":" ","pages":""},"PeriodicalIF":3.4000,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Reproduction & fertility","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1530/RAF-26-0049","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"REPRODUCTIVE BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Lay summary: Gonadotropin-releasing hormone antagonist (GnRH-ant) protocols are widely used for ovarian stimulation in fertility treatments, such as in vitro fertilization. Some research suggested GnRH-ant might affect endometrial receptivity. This could reduce the chances of embryo implantation and pregnancy. Our study included 3,764 women undergoing embryo transfer using the GnRH-ant protocol. Women were grouped by the total GnRH-ant dose they received. We compared implantation, pregnancy, and miscarriage rates across the groups. We found that pregnancy outcomes were similar regardless of the total dose used. Also, higher doses did not reduce the chances of pregnancy after embryo transfer. This suggests doctors can adjust the dose based on each patient's needs without lowering the chance of success.
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