ESTRO-EPTN guidelines for independent dose calculation and log file-based patient-specific quality assurance in scanned particle therapy

IF 3.2 Q2 ONCOLOGY

Physics and Imaging in Radiation Oncology Pub Date : 2026-09-01 Epub Date: 2026-10-10 DOI:10.1016/j.phro.2026.101109

Loïc Grevillot, Oliver Jäkel, Abdallah Qubala, Julian Horn, Adam H. Aitkenhead, Xiaoying Liang, Giuseppe Magro, Klará Badraoui-Čuprová, Jan Vilimovský, Jörg Wulff, Katrin Henkner, Catharine H. Clark, Damir Skrijelj, Ilaria Rinaldi, Kevin Souris, Séverine Rossomme, Franciska Lebbink, Liu Hong, Dawid Krzempek, Stefan Menkel, Marie Vidal

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Abstract

Background and Purpose: Independent dose calculation (IDC) and log file-based patient-specific quality assurance (PSQA) are increasingly used in scanned particle therapy (PT) to address pitfalls of phantom-based verifications. Highly modulated treatment fields, steep dose gradients, and growing interest for adaptive treatments require quality assurance (QA) approaches that are cost effective, patient-specific, and closely linked to the delivered treatment. Practical guidance is therefore needed for the safe clinical implementation of IDC- and log file-based PSQA.

Materials and Methods: The ESTRO-EPTN (European Particle Therapy Network) developed consensus-based recommendations on IDC- and log file-based PSQA in PT. Current clinical practice, commissioning strategies, risk-management approaches, and available technical solutions were evaluated. Following a review of the literature, expert-based guidelines were developed covering clinical scopes, acceptance, commissioning and validation, integration with machine QA, data management, governance, and staged implementation.

Results: IDC- and log file-based PSQA were identified as complementary elements within a quality-management framework. Log file-based approaches enable evaluation of the delivered treatment fraction(s), while IDC provides computational verification of the planned dose. When appropriately validated, these methods increase sensitivity to potentially clinically relevant deviations and can substantially reduce reliance on phantom-based measurements. Safe application requires robust machine QA, characterization of model limitations, risk analysis, and data traceability. Recommendations applicable to all centers were developed for IDC. Log file-based PSQA recommendations include minimum requirements for the vendors.

Conclusions: These recommendations aim to promote consistent and safe adoption across PT centers, while preserving the need for machine QA.

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扫描粒子治疗中独立剂量计算和基于日志文件的患者特异性质量保证的ESTRO-EPTN指南

背景和目的：独立剂量计算（IDC）和基于日志文件的患者特异性质量保证（PSQA）越来越多地用于扫描粒子治疗（PT），以解决基于幻象验证的缺陷。高度调制的治疗领域、陡峭的剂量梯度以及对适应性治疗日益增长的兴趣，需要具有成本效益、针对患者并与所提供的治疗密切相关的质量保证（QA）方法。因此，临床安全实施基于IDC和日志文件的PSQA需要实用指导。材料和方法：ESTRO-EPTN（欧洲粒子治疗网络）对基于IDC和日志文件的PT PSQA提出了基于共识的建议。目前的临床实践、调试策略、风险管理方法和可用的技术解决方案进行了评估。在回顾文献之后，专家指南的制定涵盖了临床范围、验收、调试和验证、与机器QA的集成、数据管理、治理和分阶段实施。结果：基于IDC和基于日志文件的PSQA被确定为质量管理框架中的互补元素。基于日志文件的方法能够评估输送的治疗分数，而IDC提供计划剂量的计算验证。经过适当验证后，这些方法增加了对潜在临床相关偏差的敏感性，并且可以大大减少对基于幻象的测量的依赖。安全的应用需要强大的机器质量保证，模型限制的特征，风险分析和数据可追溯性。为IDC制定了适用于所有中心的建议。基于日志文件的PSQA建议包括对供应商的最低要求。结论：这些建议旨在促进PT中心一致和安全的采用，同时保留机器质量保证的需要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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