Targeting health-related quality of life issues not found with functional outcome measures a year after aneurysm subarachnoid hemorrhage in a Swedish national cohort

IF 1.9 3区医学 Q3 CLINICAL NEUROLOGY

Acta Neurochirurgica Pub Date : 2026-10-16 Epub Date: 2026-10-17 DOI:10.1007/s00701-026-07059-z

Helena Aineskog, Bryndís Baldvinsdóttir, Ola G. Nilsson, Asgeir S. Jakola, Erik Kronvall, Elisabeth Ronne Engström, Paula Klurfan, Peter Alpkvist, Mikael Svensson, Jan Hillman, Peter Lindvall

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引用次数: 0

Abstract

Purpose

Outcome after aneurysmal subarachnoid hemorrhage (aSAH) is often devastating with life time issues also for independent survivors. We aimed to identify health related quality of life (HRQoL) issues in this favorable functional outcome group compared to a sex and age matched general population.

Methods

We have analyzed data from 634 Swedish aSAH patients from a national prospective study ranging between 2014 and 2018. One year after ictus, functional outcome was analyzed using Glasgow Outcome Scale Extended (GOSE) and HRQoL assessed by Euro-quality of life—5 dimensions—3 levels (EQ-5D-3L). Favorable GOSE (5–8) were found in 471 patients. Age- and sex-matched populations were created by published data from a cross-sectional cohort of 32,597 people living in Stockholm County in 2006. Odds ratios (ORs) for rating a specific EQ-5D-3L level were calculated for each domain. Significance was set at α = 0.001.

Results

Patients reported less mobility problems than the matched general population (9.6% vs 14.7%; OR 0.62 p = 0.002). However, with usual activities significantly more difficulties with moderate, (24.0% vs 10.9%; OR 2.58, p < .001) and any problems (27.0% vs 12.5%; OR 2.58, p < .001) were reported. More issues with extreme anxiety/depression were also reported ((5.3% vs 2.8%; OR 1.94; p = 0.002). Unfavorable GOSE patients were doing worse than the matched population in all levels and dimensions measured (Online Resource 1, 2, 3 and 4).

Conclusion

Although patients with favorable functional outcome report good or better mobility compared to their age and sex matched general population, they have significantly more issues with usual activities a year after aSAH more extreme issues with anxiety/depression were also reported To our knowledge, this is the first time EQ-5D-3L data is compared in a national group of aSAH patients with favorable functional outcome to a sex and age matched general population.

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针对瑞典国家队列中蛛网膜下腔动脉瘤出血后一年未发现功能结果测量中与健康相关的生活质量问题

目的动脉瘤性蛛网膜下腔出血（aSAH）后的结局往往是毁灭性的，对独立幸存者来说也是终生的问题。我们的目的是确定与性别和年龄匹配的普通人群相比，这一有利功能结局组的健康相关生活质量（HRQoL）问题。方法：我们分析了2014年至2018年期间一项全国性前瞻性研究中634名瑞典aSAH患者的数据。发病后1年，采用格拉斯哥结局量表（GOSE）分析功能结局，采用欧洲生活质量5维3级（EQ-5D-3L）评估HRQoL。471例患者有良好的GOSE（5-8）。年龄和性别匹配的人群是根据2006年斯德哥尔摩县32597人的横断面队列公布的数据创建的。计算每个域评价特定EQ-5D-3L水平的比值比（ORs）。显著性设为α = 0.001。结果患者报告的活动能力问题少于匹配人群（9.6% vs 14.7%; OR 0.62 p = 0.002）。然而，与正常活动相比，中度困难明显更多，（24.0% vs 10.9%; OR 2.58, p <）001)和任何问题（27.0% vs 12.5%; OR 2.58, p <）001)。更多的极端焦虑/抑郁问题也被报道(（5.3% vs 2.8%; OR 1.94; p = 0.002）。不良GOSE患者在所有水平和测量维度上的表现都比匹配人群差（在线资源1、2、3和4）。结论：虽然与年龄和性别匹配的普通人群相比，具有良好功能结局的患者报告了良好或更好的活动能力，但他们在aSAH后一年的日常活动问题明显更多，更极端的焦虑/抑郁问题也被报道。据我们所知，这是EQ-5D-3L数据首次在全国范围内比较具有良好功能结局的aSAH患者与性别和年龄匹配的普通人群。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Neurochirurgica 医学-临床神经学

CiteScore

4.40

自引率

4.20%

发文量

342

审稿时长

1 months

期刊介绍： The journal "Acta Neurochirurgica" publishes only original papers useful both to research and clinical work. Papers should deal with clinical neurosurgery - diagnosis and diagnostic techniques, operative surgery and results, postoperative treatment - or with research work in neuroscience if the underlying questions or the results are of neurosurgical interest. Reports on congresses are given in brief accounts. As official organ of the European Association of Neurosurgical Societies the journal publishes all announcements of the E.A.N.S. and reports on the activities of its member societies. Only contributions written in English will be accepted.