Epidemiology, determinants, and microbiological profile of implant-associated infections following intramedullary nailing in a tertiary hospital in Ethiopia

IF 2.2 3区医学 Q2 ORTHOPEDICS

Archives of Orthopaedic and Trauma Surgery Pub Date : 2026-10-14 DOI:10.1007/s00402-026-06535-6

Abebaw Muhabaw Zegeye, Suleiman Ayalew Belay, Ephrem Bekele Kebede, Birlew Teshome Alemayehu, Sileshi Serebe Zeleke, Yohannis Derbew Molla

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引用次数: 0

Abstract

Background

Implant-associated infections after intramedullary nailing (IMN) are a major cause of morbidity in patients with long bone fractures. This study aimed to determine the magnitude, determinants, and microbiological profile of such infections in a tertiary hospital in Ethiopia.

Methods

A hospital-based cross-sectional study was conducted among 260 patients who underwent IMN for lower extremity long bone fractures between January 2021 and December 2023. Clinical data, operative details, and microbiological results were collected, and logistic regression was applied to identify determinants of infection.

Results

The overall infection rate was 8.46% (95% CI: 5.38–12.53; 22/260), comprising 4.62% deep and 3.85% superficial infections. We found that emergency surgery and hospital stay longer than 14 days were independently associated with an increased risk of infection. Among the limited number of culture-positive infections, Gram-negative bacteria predominated, with Escherichia coli as the most frequently identified pathogen.

Conclusion

The infection rate was higher than in many other settings, underscoring the need for improved perioperative infection prevention and reduced hospital stays. Findings highlight the importance of perioperative optimization and hospital infection control in LMICs.

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埃塞俄比亚一家三级医院髓内钉后植入物相关感染的流行病学、决定因素和微生物特征

背景：髓内钉（IMN）后种植体相关感染是长骨骨折患者发病的主要原因。本研究旨在确定埃塞俄比亚三级医院此类感染的规模、决定因素和微生物特征。方法：对2021年1月至2023年12月期间接受IMN治疗下肢长骨骨折的260例患者进行了一项以医院为基础的横断面研究。收集临床资料、手术细节和微生物学结果，并应用逻辑回归来确定感染的决定因素。结果：总感染率为8.46% (95% CI: 5.38 ~ 12.53; 22/260)，其中深部感染4.62%，浅表感染3.85%。我们发现急诊手术和住院时间超过14天与感染风险增加独立相关。在数量有限的培养阳性感染中，革兰氏阴性菌占主导地位，大肠杆菌是最常见的病原体。结论：该病例感染率高于其他病例，需要加强围手术期感染预防，减少住院时间。研究结果强调了中低收入国家围手术期优化和医院感染控制的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Orthopaedic and Trauma Surgery 医学-外科

CiteScore

4.30

自引率

13.00%

发文量

424

审稿时长

2 months

期刊介绍： "Archives of Orthopaedic and Trauma Surgery" is a rich source of instruction and information for physicians in clinical practice and research in the extensive field of orthopaedics and traumatology. The journal publishes papers that deal with diseases and injuries of the musculoskeletal system from all fields and aspects of medicine. The journal is particularly interested in papers that satisfy the information needs of orthopaedic clinicians and practitioners. The journal places special emphasis on clinical relevance. "Archives of Orthopaedic and Trauma Surgery" is the official journal of the German Speaking Arthroscopy Association (AGA).