A multi-fluid exercise proteomic atlas reveals regulators of health and disease

IF 27.5 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Nature metabolism Pub Date : 2026-10-12 DOI:10.1038/s42255-026-01642-5

引用次数: 0

Abstract

A single bout of exercise triggers thousands of coordinated protein changes across blood, saliva and urine. By integrating tissue atlases, human genetics and in vivo functional validation, we present a multi-fluid resource that serves as a starting point for prioritizing robust candidate exercise-regulated proteins that might mediate the cardiometabolic health benefits of long-term exercise.

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多液体运动蛋白质组图谱揭示了健康和疾病的调节因子。

一次运动就会触发血液、唾液和尿液中数千种协调的蛋白质变化。通过整合组织图谱、人类遗传学和体内功能验证，我们提出了一种多流体资源，作为优先考虑健壮的候选运动调节蛋白的起点，这些蛋白可能介导长期运动对心脏代谢健康的益处。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

27.50

自引率

2.40%

发文量

170

期刊介绍： Nature Metabolism is a peer-reviewed scientific journal that covers a broad range of topics in metabolism research. It aims to advance the understanding of metabolic and homeostatic processes at a cellular and physiological level. The journal publishes research from various fields, including fundamental cell biology, basic biomedical and translational research, and integrative physiology. It focuses on how cellular metabolism affects cellular function, the physiology and homeostasis of organs and tissues, and the regulation of organismal energy homeostasis. It also investigates the molecular pathophysiology of metabolic diseases such as diabetes and obesity, as well as their treatment. Nature Metabolism follows the standards of other Nature-branded journals, with a dedicated team of professional editors, rigorous peer-review process, high standards of copy-editing and production, swift publication, and editorial independence. The journal has a high impact factor, has a certain influence in the international area, and is deeply concerned and cited by the majority of scholars.