A practical demand-based model for determining cyclotron irradiation time in routine 18F-FDG production.

IF 1.4 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Nuclear Medicine Communications Pub Date : 2026-10-13 DOI:10.1097/MNM.0000000000002250

Hiroshi Yamaguchi

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引用次数: 0

Abstract

Purpose: The study aimed to develop and evaluate a practical model for determining cyclotron irradiation time based on planned fluorodeoxyglucose (FDG) supply in a hospital-based production setting.

Methods: Irradiation time was calculated using a composite coefficient of 2.8 min per GBq of planned clinical demand. The coefficient integrated a facility-specific conversion between required end-of-bombardment activity and irradiation time, a conservative synthesis yield of 55%, quality control activity consumption of 11.1%, radioactive decay during an approximately 30-min processing interval, and an operational safety factor of 1.2.

Results: During a fixed 24-month evaluation period, the model was applied on 516 consecutive scheduled FDG production days. Sufficient FDG activity was supplied for all scheduled examinations on all 516 days (100%), with no activity shortage attributable to underestimation of the required irradiation time.

Conclusion: A demand-based irradiation model incorporating conservative yield assumptions, quality control consumption, and handling margins enables reliable FDG supply while maintaining an appropriate activity margin. This approach provides a practical framework for hospital-based radiopharmaceutical production.

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一种实用的基于需求的模型，用于确定常规18F-FDG生产中回旋辐照时间。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nuclear Medicine Communications 医学-核医学

CiteScore

2.20

自引率

6.70%

发文量

212

审稿时长

3-8 weeks

期刊介绍： Nuclear Medicine Communications, the official journal of the British Nuclear Medicine Society, is a rapid communications journal covering nuclear medicine and molecular imaging with radionuclides, and the basic supporting sciences. As well as clinical research and commentary, manuscripts describing research on preclinical and basic sciences (radiochemistry, radiopharmacy, radiobiology, radiopharmacology, medical physics, computing and engineering, and technical and nursing professions involved in delivering nuclear medicine services) are welcomed, as the journal is intended to be of interest internationally to all members of the many medical and non-medical disciplines involved in nuclear medicine. In addition to papers reporting original studies, frankly written editorials and topical reviews are a regular feature of the journal.