Postoperative Emergence After Remimazolam- Versus Propofol-Based Total Intravenous Anesthesia for Cardiac Valve Surgery: A Retrospective Observational Study.

IF 1.4 Q3 ANESTHESIOLOGY

Annals of Cardiac Anaesthesia Pub Date : 2026-10-01 Epub Date: 2026-10-12 DOI:10.4103/aca.aca_90_26

Emi Fujii, Yasuhiko Imashuku, Motoi Inoue, Hirotoshi Kitagawa

{"title":"Postoperative Emergence After Remimazolam- Versus Propofol-Based Total Intravenous Anesthesia for Cardiac Valve Surgery: A Retrospective Observational Study.","authors":"Emi Fujii, Yasuhiko Imashuku, Motoi Inoue, Hirotoshi Kitagawa","doi":"10.4103/aca.aca_90_26","DOIUrl":null,"url":null,"abstract":"Context: Remimazolam is an ultra-short-acting benzodiazepine used for general anesthesia, including cardiac surgery; however, its effect on postoperative emergence following cardiopulmonary bypass remains unclear.Aims: We aimed to compare postoperative emergence following remimazolam- and propofol-based total intravenous anesthesia in adult patients undergoing cardiac valve surgery.Settings and design: A retrospective observational study.Methods and materials: We included adult patients who underwent elective cardiac valve replacement surgery at a single center between April 2023 and September 2024. Patients received either remimazolam- or propofol-based total intravenous anesthesia according to institutional practice. The primary endpoint was postoperative emergence time. Secondary endpoints included time to extubation and early postoperative hemodynamic stability assessed using the vasoactive-inotropic score.Statistical analysis used: Baseline characteristics and perioperative variables were compared between the groups. Univariate and multivariable linear regression analyses were performed.Results: Sixty-three patients were included in the analysis (remimazolam group, n = 21; propofol group, n = 42). Postoperative emergence time did not differ significantly between the two groups (164 [120-253] min vs. 137 [95-188] min, P = 0.193). Time to extubation was also comparable between the groups (1,009 [914-1,070] min vs. 1,033 [906-1,057] min, P = 0.844). Early postoperative hemodynamic parameters, including vasoactive-inotropic scores, were comparable between the two groups.Conclusions: In adult patients undergoing cardiac valve surgery, postoperative emergence time was comparable between remimazolam- and propofol-based total intravenous anesthesia. More prospective studies are warranted to clarify the role of remimazolam in cardiac anesthesia.","PeriodicalId":7997,"journal":{"name":"Annals of Cardiac Anaesthesia","volume":"29 4","pages":"570-576"},"PeriodicalIF":1.4000,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Cardiac Anaesthesia","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/aca.aca_90_26","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/10/12 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"ANESTHESIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Context: Remimazolam is an ultra-short-acting benzodiazepine used for general anesthesia, including cardiac surgery; however, its effect on postoperative emergence following cardiopulmonary bypass remains unclear.

Aims: We aimed to compare postoperative emergence following remimazolam- and propofol-based total intravenous anesthesia in adult patients undergoing cardiac valve surgery.

Settings and design: A retrospective observational study.

Methods and materials: We included adult patients who underwent elective cardiac valve replacement surgery at a single center between April 2023 and September 2024. Patients received either remimazolam- or propofol-based total intravenous anesthesia according to institutional practice. The primary endpoint was postoperative emergence time. Secondary endpoints included time to extubation and early postoperative hemodynamic stability assessed using the vasoactive-inotropic score.

Statistical analysis used: Baseline characteristics and perioperative variables were compared between the groups. Univariate and multivariable linear regression analyses were performed.

Results: Sixty-three patients were included in the analysis (remimazolam group, n = 21; propofol group, n = 42). Postoperative emergence time did not differ significantly between the two groups (164 [120-253] min vs. 137 [95-188] min, P = 0.193). Time to extubation was also comparable between the groups (1,009 [914-1,070] min vs. 1,033 [906-1,057] min, P = 0.844). Early postoperative hemodynamic parameters, including vasoactive-inotropic scores, were comparable between the two groups.

Conclusions: In adult patients undergoing cardiac valve surgery, postoperative emergence time was comparable between remimazolam- and propofol-based total intravenous anesthesia. More prospective studies are warranted to clarify the role of remimazolam in cardiac anesthesia.

查看原文本刊更多论文

心脏瓣膜手术中雷马唑仑与异丙酚全静脉麻醉的对比：一项回顾性观察研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Annals of Cardiac Anaesthesia ANESTHESIOLOGY-

CiteScore

1.60

自引率

0.00%

发文量

147

审稿时长

26 weeks

期刊介绍： Annals of Cardiac Anaesthesia (ACA) is the official journal of the Indian Association of Cardiovascular Thoracic Anaesthesiologists. The journal is indexed with PubMed/MEDLINE, Excerpta Medica/EMBASE, IndMed and MedInd. The journal’s full text is online at www.annals.in. With the aim of faster and better dissemination of knowledge, we will be publishing articles ‘Ahead of Print’ immediately on acceptance. In addition, the journal would allow free access (Open Access) to its contents, which is likely to attract more readers and citations to articles published in ACA. Authors do not have to pay for submission, processing or publication of articles in ACA.