Cardioprotection Is a Delivery Problem: A First-Medical-Contact Framework for Acute Myocardial Infarction

IF 3.7 Q1 CHEMISTRY, MEDICINAL

ACS Pharmacology and Translational Science Pub Date : 2026-10-09 Epub Date: 2026-09-17 DOI:10.1021/acsptsci.6c00552

Vibhudutta Awasthi, Tarun W. Dasari, Kenichi A. Tanaka

引用次数: 0

Abstract

Dozens of agents that limit reperfusion injury preclinically have failed clinically. These failures are architectural, not biological: the right biology reaches the wrong place, as the wrong molecule, at the wrong time, judged by the wrong end point. We recast each as a design constraint and specify a staged regimen anchored at first medical contact.

查看原文本刊更多论文

心脏保护是一个传递问题：急性心肌梗死的首次医疗接触框架

数十种临床前限制再灌注损伤的药物在临床上失败了。这些失败是建筑上的，而不是生物学上的：正确的生物学在错误的时间到达了错误的地方，作为错误的分子，由错误的终点判断。我们重新定义了每个设计约束，并指定了以首次医疗接触为基础的分阶段治疗方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

ACS Pharmacology and Translational Science Medicine-Pharmacology (medical)

CiteScore

10.00

自引率

3.30%

发文量

133

期刊介绍： ACS Pharmacology & Translational Science publishes high quality, innovative, and impactful research across the broad spectrum of biological sciences, covering basic and molecular sciences through to translational preclinical studies. Clinical studies that address novel mechanisms of action, and methodological papers that provide innovation, and advance translation, will also be considered. We give priority to studies that fully integrate basic pharmacological and/or biochemical findings into physiological processes that have translational potential in a broad range of biomedical disciplines. Therefore, studies that employ a complementary blend of in vitro and in vivo systems are of particular interest to the journal. Nonetheless, all innovative and impactful research that has an articulated translational relevance will be considered. ACS Pharmacology & Translational Science does not publish research on biological extracts that have unknown concentration or unknown chemical composition. Authors are encouraged to use the pre-submission inquiry mechanism to ensure relevance and appropriateness of research.