Physical Activity, Intrinsic Capacity and Frailty Risk in Middle-Aged and Older Adults: Evidence From the CHARLS and ELSA Cohorts

IF 1.8 4区医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Health & Social Care in the Community Pub Date : 2026-10-09 DOI:10.1155/hsc/2133282

Huan Feng, Tianyue Zhao, Yunan Zhang, Shengjie Wang

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引用次数: 0

Abstract

Objective

To examine associations of physical activity (PA) and intrinsic capacity (IC) with incident frailty.

Methods

Adults aged ≥ 50 years from CHARLS (n = 1519) and ELSA (n = 4897) were analysed. PA was questionnaire-assessed; six-domain IC was classified as robust, preimpaired or impaired; incident frailty was defined as Frailty Index ≥ 0.25. Cox models estimated adjusted hazard ratios (HRs).

Results

Robust versus impaired IC was associated with lower frailty hazard in CHARLS (HR 0.42, 95% CI 0.32–0.55) and ELSA (HR 0.40, 95% CI 0.31–0.51). PA was associated with lower hazard in ELSA (HR 0.64, 95% CI 0.55–0.75) but not CHARLS (HR 0.94, 95% CI 0.77–1.16); the PA × cohort interaction was significant (p < 0.001). Active + robust showed the lowest hazard in CHARLS (HR 0.38, 95% CI 0.27–0.55) and ELSA (HR 0.36, 95% CI 0.25–0.53).

Conclusion

Preserved IC was consistently associated with lower frailty risk, supporting joint assessment while accounting for cohort-specific PA measurement.

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中老年人的体力活动、内在能力和衰弱风险：来自CHARLS和ELSA队列的证据

目的探讨体力活动（PA）和内在能力（IC）与偶发性虚弱的关系。方法对年龄≥50岁的CHARLS患者（1519例）和ELSA患者（4897例）进行分析。PA采用问卷评估；六域集成电路分为稳健型、预受损型和受损型；脆弱性指数≥0.25定义为事件脆弱性。Cox模型估计调整后的风险比（hr）。结果：在CHARLS （HR 0.42, 95% CI 0.32-0.55）和ELSA （HR 0.40, 95% CI 0.31-0.51）中，健全IC与受损IC的衰弱风险较低相关。PA与ELSA的风险较低相关（HR 0.64, 95% CI 0.55-0.75），但与CHARLS无关（HR 0.94, 95% CI 0.77-1.16）；PA与队列相互作用显著（p < 0.001）。Active + robust在CHARLS （HR 0.38, 95% CI 0.27-0.55）和ELSA （HR 0.36, 95% CI 0.25-0.53）的风险最低。结论保留IC始终与较低的衰弱风险相关，支持联合评估，同时考虑到队列特定的PA测量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Health & Social Care in the Community Multiple-

CiteScore

4.50

自引率

8.30%

发文量

423

期刊介绍： Health and Social Care in the community is an essential journal for anyone involved in nursing, social work, physiotherapy, occupational therapy, general practice, health psychology, health economy, primary health care and the promotion of health. It is an international peer-reviewed journal supporting interdisciplinary collaboration on policy and practice within health and social care in the community. The journal publishes: - Original research papers in all areas of health and social care - Topical health and social care review articles - Policy and practice evaluations - Book reviews - Special issues