H5 influenza virus mRNA-lipid nanoparticle (LNP) vaccination elicits adaptive immune responses in Holstein calves.

IF 4.1 2区医学 Q2 VIROLOGY

Journal of Virology Pub Date : 2026-10-08 DOI:10.1128/jvi.01289-26

Carine K Souza, Jefferson J S Santos, Paola Boggiatto, Haley Sterle, Bailey Arruda, Mitchell V Palmer, Alessandra Campos, Jiaojiao Liu, Naiqing Ye, Drew Weissmann, Scott E Hensley, Amy L Baker

引用次数: 0

Abstract

Highly pathogenic avian influenza (HPAI) clade 2.3.4.4b H5N1 circulated widely in lactating dairy cows in the United States following the initial detection in 2024. Due to the critical need for intervention strategies for this outbreak, we evaluated antibody and cellular immune responses of a clade 2.3.4.4b H5 mRNA-LNP vaccine in calves. We found that the H5 mRNA-LNP vaccine induced a robust antibody and CD8⁺ T cell-mediated immune response and conferred protection against clade 2.3.4.4b H5N1 infection.IMPORTANCEIt is important to develop vaccines that limit clade 2.3.4.4b H5N1 infection in cattle. In this study, we found that a new H5 mRNA-lipid nanoparticle vaccine is immunogenic when delivered intramuscularly to male Holstein calves.

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H5流感病毒mrna -脂质纳米颗粒（LNP）疫苗接种可引起荷斯坦小牛的适应性免疫反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Virology 医学-病毒学

CiteScore

10.10

自引率

7.40%

发文量

906

审稿时长

1 months

期刊介绍： Journal of Virology (JVI) explores the nature of the viruses of animals, archaea, bacteria, fungi, plants, and protozoa. We welcome papers on virion structure and assembly, viral genome replication and regulation of gene expression, genetic diversity and evolution, virus-cell interactions, cellular responses to infection, transformation and oncogenesis, gene delivery, viral pathogenesis and immunity, and vaccines and antiviral agents.