Banding Karyotyping From Peripheral Blood Is a Useful Method for the Diagnostic Workup of Myelodysplastic Neoplasia and CMML

IF 2.3 2区医学 Q2 GENETICS & HEREDITY

Genes, Chromosomes & Cancer Pub Date : 2026-10-09 DOI:10.1002/gcc.70177

Cornelia Heusler, Barbara Hildebrandt, Felicitas Schulz, Kathrin Nachtkamp, Corinna Strupp, Valerie Flatten, Sascha Dietrich, Norbert Gattermann, Ulrich Germing

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Abstract

This retrospective study involving 155 patients from the Düsseldorf MDS Registry compared cytogenetic banding from peripheral blood (PB) and bone marrow (BM) in patients with myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemia (CMML). For 63 of these patients, paired PB and BM cytogenetic analyses were available that were conducted no more than 3 months apart. Concordant ISCN results were found in 81%, with no significant differences in the total number of metaphases or aberrant metaphases between PB and BM. Furthermore, IPSS-R/-M scorings, derived from PB and BM, turned out to be comparable, with only 7 out of 63 patients classified into a different cytogenetic risk category. This implies that aberrant clones are not underrepresented in PB and that cytogenetic findings from PB can reliably reflect those obtained from BM.

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外周血带型核型是诊断骨髓增生异常瘤和CMML的有效方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Genes, Chromosomes & Cancer 医学-遗传学

CiteScore

7.00

自引率

8.10%

发文量

审稿时长

4-8 weeks

期刊介绍： Genes, Chromosomes & Cancer will offer rapid publication of original full-length research articles, perspectives, reviews and letters to the editors on genetic analysis as related to the study of neoplasia. The main scope of the journal is to communicate new insights into the etiology and/or pathogenesis of neoplasia, as well as molecular and cellular findings of relevance for the management of cancer patients. While preference will be given to research utilizing analytical and functional approaches, descriptive studies and case reports will also be welcomed when they offer insights regarding basic biological mechanisms or the clinical management of neoplastic disorders.