Heterochiral peptides reshaping class B1 GPCR agonism.

IF 24 1区医学 Q1 PHARMACOLOGY & PHARMACY

Trends in pharmacological sciences Pub Date : 2026-10-01 DOI:10.1016/j.tips.2026.09.003

Heng Liu, Jianfeng Cai

引用次数: 0

Abstract

A α-helical conformation within Class B1 G protein-coupled receptors agonists has been thought necessary for receptor activation. Gellman et al. suggested that selective replacement of L-amino acids with D-enantiomers could yield biased agonists. The new strategy helical would broaden the tools available for investigating agonist conformations and therapeutic potentials.

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异手性肽重塑B1类GPCR激动作用。

B1类G蛋白偶联受体激动剂中的α-螺旋构象被认为是受体激活的必要条件。Gellman等人认为，用d -对映体选择性替代l -氨基酸可以产生偏倚的激动剂。新的策略螺旋将扩大工具可用于研究激动剂构象和治疗潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in pharmacological sciences 医学-药学

CiteScore

23.90

自引率

0.70%

发文量

132

审稿时长

6-12 weeks

期刊介绍： Trends in Pharmacological Sciences (TIPS) is a monthly peer-reviewed reviews journal that focuses on a wide range of topics in pharmacology, pharmacy, pharmaceutics, and toxicology. Launched in 1979, TIPS publishes concise articles discussing the latest advancements in pharmacology and therapeutics research. The journal encourages submissions that align with its core themes while also being open to articles on the biopharma regulatory landscape, science policy and regulation, and bioethics. Each issue of TIPS provides a platform for experts to share their insights and perspectives on the most exciting developments in the field. Through rigorous peer review, the journal ensures the quality and reliability of published articles. Authors are invited to contribute articles that contribute to the understanding of pharmacology and its applications in various domains. Whether it's exploring innovative drug therapies or discussing the ethical considerations of pharmaceutical research, TIPS provides a valuable resource for researchers, practitioners, and policymakers in the pharmacological sciences.