Surgical and Clinical Outcomes of Kidney Transplantation in Obese Recipients: A Single-Center Retrospective Study from Switzerland

IF 1.8 4区医学 Q2 SURGERY

Clinical Transplantation Pub Date : 2026-10-06 DOI:10.1111/ctr.70709

Eliot Melera, Lorenzo Costa, Céline Deslarzes-Dubuis, Sébastien Déglise, Alban Longchamp, Matthieu Halfon, Jean-Pierre Venetz, Dela Golshayan, Manuel Pascual, Maurice Matter, Tobias Zingg, David Martin

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引用次数: 0

Abstract

Background

The impact of recipient obesity on kidney transplant outcomes remains controversial. This study aimed to assess the effect of recipient obesity on short- and long-term outcomes following kidney transplantation (KT).

Methods

This single-center retrospective cohort study included all consecutive adult patients who underwent KT between January 1999 and December 2023 at the Transplantation Center of Lausanne University Hospital (CHUV), Lausanne, Switzerland. Surgical complications, delayed graft function (DGF), and graft survival were compared between obese (BMI ≥ 30 kg/m²) and non-obese recipients (BMI < 30 kg/m²).

Results

A total of 953 patients were included, of whom 150 (16%) were obese. Obesity was associated with higher rates of surgical site infections (11% vs. 3%, p < 0.001), overall infections (29% vs. 5%, p < 0.001), lymphoceles (18% vs. 10%, p = 0.007), and incisional hernias (10% vs. 5%, p = 0.032). Length of hospital stay (19 vs. 17 days, p = 0.038) and DGF rates (21% vs. 14%, p = 0.024) were also higher in obese recipients. Patient survival (HR 1.09, 95% CI 0.59–1.99; p = 0.766) and death-censored graft survival (HR 0.92, 95% CI 0.29–2.92; p = 0.886) were comparable between groups at a median follow-up of 7.3 years (IQR, 3.3–12.4).

Conclusions

Recipient obesity was associated with an increased risk of surgical complications and DGF, resulting in longer hospital stays. However, it did not adversely affect long-term patient or graft survival. Therefore, despite higher early complications, obesity should not be considered a contraindication to KT.

查看原文本刊更多论文

肥胖肾移植受者的手术和临床结果：来自瑞士的单中心回顾性研究。

背景：受体肥胖对肾移植结果的影响仍然存在争议。本研究旨在评估受体肥胖对肾移植（KT）后短期和长期预后的影响。方法：这项单中心回顾性队列研究纳入了1999年1月至2023年12月在瑞士洛桑大学医院（CHUV）移植中心接受KT手术的所有连续成年患者。比较肥胖（BMI≥30 kg/m2）和非肥胖（BMI < 30 kg/m2）受体的手术并发症、移植物功能延迟（DGF）和移植物存活率。结果：共纳入953例患者，其中肥胖150例（16%）。肥胖与较高的手术部位感染率（11%对3%，p < 0.001）、总体感染率（29%对5%，p < 0.001）、淋巴囊肿（18%对10%，p = 0.007）和切口疝（10%对5%，p = 0.032）相关。肥胖接受者的住院时间（19天对17天，p = 0.038）和DGF率（21%对14%，p = 0.024）也更高。患者生存率（HR 1.09, 95% CI 0.59-1.99; p = 0.766）和死亡剔除的移植物生存率（HR 0.92, 95% CI 0.29-2.92; p = 0.886）在中位随访7.3年（IQR, 3.3-12.4）时组间具有可比性。结论：受体肥胖与手术并发症和DGF风险增加相关，导致住院时间延长。然而，它没有对患者或移植物的长期生存产生不利影响。因此，尽管早期并发症较高，肥胖不应被视为KT的禁忌症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Transplantation 医学-外科

CiteScore

3.70

自引率

4.80%

发文量

286

审稿时长

2 months

期刊介绍： Clinical Transplantation: The Journal of Clinical and Translational Research aims to serve as a channel of rapid communication for all those involved in the care of patients who require, or have had, organ or tissue transplants, including: kidney, intestine, liver, pancreas, islets, heart, heart valves, lung, bone marrow, cornea, skin, bone, and cartilage, viable or stored. Published monthly, Clinical Transplantation’s scope is focused on the complete spectrum of present transplant therapies, as well as also those that are experimental or may become possible in future. Topics include: Immunology and immunosuppression; Patient preparation; Social, ethical, and psychological issues; Complications, short- and long-term results; Artificial organs; Donation and preservation of organ and tissue; Translational studies; Advances in tissue typing; Updates on transplant pathology;. Clinical and translational studies are particularly welcome, as well as focused reviews. Full-length papers and short communications are invited. Clinical reviews are encouraged, as well as seminal papers in basic science which might lead to immediate clinical application. Prominence is regularly given to the results of cooperative surveys conducted by the organ and tissue transplant registries. Clinical Transplantation: The Journal of Clinical and Translational Research is essential reading for clinicians and researchers in the diverse field of transplantation: surgeons; clinical immunologists; cryobiologists; hematologists; gastroenterologists; hepatologists; pulmonologists; nephrologists; cardiologists; and endocrinologists. It will also be of interest to sociologists, psychologists, research workers, and to all health professionals whose combined efforts will improve the prognosis of transplant recipients.