Correcting Vitamin D Deficiency to Prevent Paclitaxel-Induced Peripheral Neuropathy: A Practice Change Evaluation.

IF 0.9 4区医学 Q3 NURSING

Clinical journal of oncology nursing Pub Date : 2026-09-30 DOI:10.1188/26.CJON.375-379

Ranju Jha Singh, Susan M Schneider, Julie A Thompson, Abir Khan, Mary Lou Affronti

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引用次数: 0

Abstract

Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a persistent problem in ambulatory oncology and is associated with low serum vitamin D levels.

Objectives: This quality improvement project evaluated a practice change at a rural community cancer center (preimplementation: N = 20; postimplementation: N = 27) aimed at mitigating CIPN associated with paclitaxel treatment in patients with breast cancer by recommending vitamin D supplementation. The key goal was to reduce CIPN incidence by at least 10%.

Methods: A pre-/postimplementation comparison of CIPN incidence among patients with breast cancer receiving paclitaxel was used before (January 2022 to December 2023) and after (June 2024 to December 2024) a practice change recommending vitamin D supplementation.

Findings: CIPN incidence decreased from 80% (n = 16 of 20) preimplementation to 67% (n = 18 of 27) postimplementation, a 13% reduction that met the 10% goal. All patients with vitamin D insufficiency (N = 11) developed CIPN.

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纠正维生素D缺乏症预防紫杉醇诱导的周围神经病变：实践改变评估。

背景：化疗诱导的周围神经病变（CIPN）是门诊肿瘤学中的一个持续问题，与血清维生素D水平低有关。目的：本质量改进项目评估了农村社区癌症中心的实践变化（实施前：N = 20；实施后：N = 27），旨在通过推荐补充维生素D来减轻乳腺癌患者紫杉醇治疗相关的CIPN。主要目标是将CIPN发生率降低至少10%。方法：在推荐补充维生素D之前（2022年1月至2023年12月）和之后（2024年6月至2024年12月），对接受紫杉醇治疗的乳腺癌患者的CIPN发生率进行了术前/术后比较。结果：CIPN发生率从实施前的80% （n = 16 / 20）下降到实施后的67% (n = 18 / 27)，减少了13%，达到了10%的目标。所有维生素D不足的患者（N = 11）均发生CIPN。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical journal of oncology nursing ONCOLOGY-NURSING

CiteScore

1.70

自引率

9.10%

发文量

127

审稿时长

6-12 weeks

期刊介绍： The Clinical Journal of Oncology Nursing (CJON) is an official publication of the Oncology Nursing Society (ONS) and is directed to the practicing nurse specializing in the care of patients with an actual or potential diagnosis of cancer. CJON is a vehicle to promote the mission of ONS, which is to advance excellence in oncology nursing and quality cancer care. The CJON mission is twofold: to provide practical information necessary to care for patients and their families across the cancer continuum and to develop publication skills in oncology nurses.