Beyond BMI: The diet-microbiome context of the obesity paradox.

IF 56.1 1区医学 Q1 CELL BIOLOGY

Cancer Cell Pub Date : 2026-10-12 Epub Date: 2026-09-30 DOI:10.1016/j.ccell.2026.08.019

En-Wei Tao, Jing-Yuan Fang, Ying-Xuan Chen

引用次数: 0

Abstract

In Nature, Desharnais et al. show that in diverse mouse models, anti-PD-1 sensitivity is more closely linked to the diet-microbiome-metabolite ecosystem than to obesity-associated metabolic dysfunction. Their findings reinforce body mass index (BMI) as an incomplete proxy for host biology and suggest strategies to improve anti-PD-1 efficacy without inducing obesity.

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超越BMI：肥胖悖论的饮食-微生物背景。

在Nature杂志上，Desharnais等人表明，在不同的小鼠模型中，抗pd -1敏感性与饮食-微生物-代谢物生态系统的关系比与肥胖相关的代谢功能障碍更密切。他们的研究结果加强了身体质量指数（BMI）作为宿主生物学的不完全代表，并提出了在不诱导肥胖的情况下提高抗pd -1疗效的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Cell 医学-肿瘤学

CiteScore

55.20

自引率

1.20%

发文量

179

审稿时长

4-8 weeks

期刊介绍： Cancer Cell is a journal that focuses on promoting major advances in cancer research and oncology. The primary criteria for considering manuscripts are as follows: Major advances: Manuscripts should provide significant advancements in answering important questions related to naturally occurring cancers. Translational research: The journal welcomes translational research, which involves the application of basic scientific findings to human health and clinical practice. Clinical investigations: Cancer Cell is interested in publishing clinical investigations that contribute to establishing new paradigms in the treatment, diagnosis, or prevention of cancers. Insights into cancer biology: The journal values clinical investigations that provide important insights into cancer biology beyond what has been revealed by preclinical studies. Mechanism-based proof-of-principle studies: Cancer Cell encourages the publication of mechanism-based proof-of-principle clinical studies, which demonstrate the feasibility of a specific therapeutic approach or diagnostic test.