Ekaterina A. Verochkina, Nadezhda V. Vchislo, Victoria G. Fedoseeva
{"title":"From α,β-Unsaturated Aldehydes to Six-Membered Heterocycles: Modern Synthesis of Thiazines and Oxazines","authors":"Ekaterina A. Verochkina, Nadezhda V. Vchislo, Victoria G. Fedoseeva","doi":"10.1002/jhet.70235","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>Thiazine and oxazine derivatives are important heterocyclic structural motifs that confer biological activity. These compounds have extensive applications in a variety of fields, including medicine, materials science, agriculture, and organic chemistry. This review provides a comprehensive analysis of current trends in the synthesis of thiazines and oxazines, as well as their isomeric forms via α,β-enal transformations. The structural features of the substrates, their influence on the selectivity and yields of the target products, reaction conditions, types of catalysts, transformation mechanisms, and prospects for the application of the obtained heterocycles are discussed in detail. Works published since 2015 are highlighted, and earlier sources are referenced as needed.</p>\n </div>","PeriodicalId":194,"journal":{"name":"Journal of Heterocyclic Chemistry","volume":"63 10","pages":"1573-1587"},"PeriodicalIF":2.9000,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Heterocyclic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jhet.70235","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/8/18 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
Thiazine and oxazine derivatives are important heterocyclic structural motifs that confer biological activity. These compounds have extensive applications in a variety of fields, including medicine, materials science, agriculture, and organic chemistry. This review provides a comprehensive analysis of current trends in the synthesis of thiazines and oxazines, as well as their isomeric forms via α,β-enal transformations. The structural features of the substrates, their influence on the selectivity and yields of the target products, reaction conditions, types of catalysts, transformation mechanisms, and prospects for the application of the obtained heterocycles are discussed in detail. Works published since 2015 are highlighted, and earlier sources are referenced as needed.
期刊介绍：
The Journal of Heterocyclic Chemistry is interested in publishing research on all aspects of heterocyclic chemistry, especially development and application of efficient synthetic methodologies and strategies for the synthesis of various heterocyclic compounds. In addition, Journal of Heterocyclic Chemistry promotes research in other areas that contribute to heterocyclic synthesis/application, such as synthesis design, reaction techniques, flow chemistry and continuous processing, multiphase catalysis, green chemistry, catalyst immobilization and recycling.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
