DDIAS shields vulnerable single-stranded DNA to direct neurogenesis and protect cancer cells

IF 16 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cell Pub Date : 2026-10-01 DOI:10.1016/j.molcel.2026.08.026

Ashok R. Venkitaraman

引用次数: 0

Abstract

Papers in Molecular Cell and Cell by Xue et al.1 and Tsukuda2 et al., respectively, reveal that DDIAS serves as an essential single-stranded DNA (ssDNA)-binding effector of the CIP2A-TOPBP1 complex that safeguards genome integrity by shielding post-replicative ssDNA lesions during mitosis, with implications for human cancer and neurodevelopment.

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DDIAS保护脆弱的单链DNA来指导神经发生和保护癌细胞

Xue et al.1和Tsukuda2 et al.分别在Molecular Cell和Cell上发表的论文表明，DDIAS是CIP2A-TOPBP1复合体的重要单链DNA （ssDNA）结合效应物，在有丝分裂期间通过屏蔽复制后ssDNA损伤来保护基因组完整性，对人类癌症和神经发育具有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Cell 生物-生化与分子生物学

CiteScore

26.00

自引率

3.80%

发文量

389

审稿时长

1 months

期刊介绍： Molecular Cell is a companion to Cell, the leading journal of biology and the highest-impact journal in the world. Launched in December 1997 and published monthly. Molecular Cell is dedicated to publishing cutting-edge research in molecular biology, focusing on fundamental cellular processes. The journal encompasses a wide range of topics, including DNA replication, recombination, and repair; Chromatin biology and genome organization; Transcription; RNA processing and decay; Non-coding RNA function; Translation; Protein folding, modification, and quality control; Signal transduction pathways; Cell cycle and checkpoints; Cell death; Autophagy; Metabolism.