Hypoxia? NNoT a PROblem!

IF 16 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cell Pub Date : 2026-10-01 DOI:10.1016/j.molcel.2026.09.007

Ningning Liang,Costas A. Lyssiotis,Daniel R. Wahl

引用次数: 0

Abstract

Glioma cells experience profound metabolic stress in hypoxic tumor regions, where mitochondrial respiration is constrained and redox balance becomes difficult to maintain. A recent study by Vettore and colleagues1 in Molecular Cell identifies nicotinamide nucleotide transhydrogenase as a key mitochondrial enzyme that connects NADH oxidation to NADPH production, thereby supporting proline synthesis and growth under hypoxia. This work highlights how distinct redox pools are coordinated in cancer cells and suggests that NNT-dependent metabolism may represent a vulnerability in hypoxic tumors.

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缺氧吗?没问题！

胶质瘤细胞在低氧肿瘤区经历深刻的代谢应激，线粒体呼吸受到限制，氧化还原平衡难以维持。Vettore及其同事最近在《分子细胞》（Molecular Cell）杂志上的一项研究发现，烟酰胺核苷酸转氢酶是连接NADH氧化和NADPH生成的关键线粒体酶，从而支持脯氨酸在缺氧条件下的合成和生长。这项工作强调了不同的氧化还原池在癌细胞中是如何协调的，并表明nnt依赖的代谢可能代表了缺氧肿瘤的脆弱性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Cell 生物-生化与分子生物学

CiteScore

26.00

自引率

3.80%

发文量

389

审稿时长

1 months

期刊介绍： Molecular Cell is a companion to Cell, the leading journal of biology and the highest-impact journal in the world. Launched in December 1997 and published monthly. Molecular Cell is dedicated to publishing cutting-edge research in molecular biology, focusing on fundamental cellular processes. The journal encompasses a wide range of topics, including DNA replication, recombination, and repair; Chromatin biology and genome organization; Transcription; RNA processing and decay; Non-coding RNA function; Translation; Protein folding, modification, and quality control; Signal transduction pathways; Cell cycle and checkpoints; Cell death; Autophagy; Metabolism.