Chromatin plasticity and lineage repurposing: When gastric identity turns acidic

IF 56.1 1区医学 Q1 CELL BIOLOGY

Cancer Cell Pub Date : 2026-10-07 DOI:10.1016/j.ccell.2026.09.010

Xiaotian Zhang,Yakun Wang,Xiaoyi Chong,Jiabao Wang,Wenfei Li

引用次数: 0

Abstract

Chromatin dynamics shape gastric cancer at every stage. In this issue of Cancer Cell, Wang et al. uncover a premalignant chromatin state primed for oncogenic activation alongside a pseudo-gastric subtype that hijacks acid secretion to evade antitumor immunity, revealing gastric proton pumps as a potential therapeutic target.

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染色质的可塑性和谱系的重新利用：当胃的身份变成酸性

染色质动力学决定了胃癌的各个阶段。在这一期的《Cancer Cell》杂志上，Wang等人发现了一种引发致癌激活的癌前染色质状态，以及一种劫持酸分泌以逃避抗肿瘤免疫的假胃亚型，揭示了胃质子泵是一种潜在的治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Cell 医学-肿瘤学

CiteScore

55.20

自引率

1.20%

发文量

179

审稿时长

4-8 weeks

期刊介绍： Cancer Cell is a journal that focuses on promoting major advances in cancer research and oncology. The primary criteria for considering manuscripts are as follows: Major advances: Manuscripts should provide significant advancements in answering important questions related to naturally occurring cancers. Translational research: The journal welcomes translational research, which involves the application of basic scientific findings to human health and clinical practice. Clinical investigations: Cancer Cell is interested in publishing clinical investigations that contribute to establishing new paradigms in the treatment, diagnosis, or prevention of cancers. Insights into cancer biology: The journal values clinical investigations that provide important insights into cancer biology beyond what has been revealed by preclinical studies. Mechanism-based proof-of-principle studies: Cancer Cell encourages the publication of mechanism-based proof-of-principle clinical studies, which demonstrate the feasibility of a specific therapeutic approach or diagnostic test.