Palladium-Catalyzed Enantioselective Dearomative Domino Heck/Stille Reaction of Indoles

IF 4.7 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2026-10-16 Epub Date: 2026-10-06 DOI:10.1021/acs.orglett.6c03404

Chuan-Jun Lu, Bing-Bing Huang, Fei Xie, Ren-Xiao Liang, Yi-Xia Jia, Ren-Rong Liu

引用次数: 0

Abstract

Palladium-catalyzed enantioselective dearomative difunctionalization of N-substituted indoles was developed via dearomative carbonpalladation and subsequent capture of benzyl-Pd species by organostannane reagents (domino Heck/Stille reaction). A wide range of 2,3-disubstituted chiral indolines bearing vicinal quaternary and tertiary stereocenters was efficiently synthesized in one step with excellent enantioselectivities and diastereoselectivities.

查看原文本刊更多论文

钯催化吲哚的对映选择性脱香DominoHeck/Stille反应

摘要钯催化n -取代吲哚的对映选择性脱芳双官能化反应是通过脱芳碳钯化和随后的有机硅试剂捕获苯基pd（多米诺Heck/Stille反应）。具有对映选择性和非对映选择性的2,3-二取代手性吲哚类邻季位和叔位立体中心在一步内合成。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.