Anaïs Chhang, Clément Dumont, Florian Herms, Bénédicte Cavelier-Balloy, Pierre Mongiat-Artus, François Desgrandchamps, Annabelle Goujon
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引用次数: 0
Abstract
Background: Penile squamous cell carcinoma (PSCC) is a rare malignancy that may develop following persistent infection with human papillomavirus (HPV). The prognostic value of HPV status remains controversial.
Objective: To evaluate the impact of p16 status, a surrogate marker of high-risk HPV-driven carcinogenesis, and selected histopathological features on survival outcomes in PSCC, and to assess their interrelationships.
Design, setting and participants: This retrospective single-center study included 87 patients treated for PSCC at Saint-Louis Hospital (Paris, France) between 2015 and 2024.
Outcome measurements and statistical analyses: Associations between p16 status and histopathological features (pT stage, pN stage, tumor grade, lymphovascular invasion, and perineural invasion) were assessed using Chi-squared tests. Their impact on disease-specific survival (DSS) and overall survival (OS) was analyzed using Kaplan-Meier curves and log-rank tests.
Results: Thirty-seven patients (43%) had p16-positive tumors. p16 status was not associated with tumor stage, nodal status, lymphovascular invasion, or perineural invasion. p16-positive tumors were significantly associated with higher histological grade (P<0.001). Factors associated with poorer 3-year DSS included nodal involvement (54.4 vs. 100%, P<0.001), lymphovascular invasion (52.5 vs. 90.9%, P=0.024), and perineural invasion (59.9 vs. 91.4%, p<0.01). p16 status was not associated with DSS (P=0.68).
Conclusions: In this retrospective single-center cohort, p16 status was not significantly associated with DSS in univariate analysis. Nodal involvement, lymphovascular invasion, and perineural invasion were the variables most strongly associated with prognosis in the univariate analyses.
背景：阴茎鳞状细胞癌（PSCC）是一种罕见的恶性肿瘤，可在持续感染人乳头瘤病毒（HPV）后发展。HPV状态的预后价值仍有争议。目的：评估p16状态（hpv驱动的高危癌变的替代标志物）和选定的组织病理学特征对PSCC生存结局的影响，并评估它们之间的相互关系。设计、环境和参与者：这项回顾性单中心研究包括2015年至2024年间在法国巴黎圣路易医院（Saint-Louis Hospital）接受PSCC治疗的87例患者。结果测量和统计分析：使用卡方检验评估p16状态与组织病理学特征（pT分期、pN分期、肿瘤分级、淋巴血管侵犯和神经周围侵犯）之间的关系。采用Kaplan-Meier曲线和log-rank检验分析其对疾病特异性生存（DSS）和总生存（OS）的影响。结果：p16阳性肿瘤37例（43%）。P16状态与肿瘤分期、淋巴结状态、淋巴血管浸润或神经周围浸润无关。p16阳性肿瘤与较高的组织学分级显著相关（p < 0.001）。与3年DSS较差相关的因素包括淋巴结受累（54.4% vs 100%, p < 0.001）、淋巴血管侵犯（52.5% vs 90.9%, p = 0.024）和神经周围侵犯（59.9% vs 91.4%, p < 0.01）。p16状态与DSS无相关性（p = 0.68）。结论：在这一回顾性单中心队列中，单因素分析显示p16状态与DSS无显著相关。在单变量分析中，淋巴结受累、淋巴血管侵犯和神经周围侵犯是与预后最密切相关的变量。
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