Surgery without postoperative adjuvant therapy for dissecting cellulitis of the scalp: a retrospective study of a selected cohort.

IF 3.9
Junyou Zheng, Rundong Zhang, Ke Zhang, Qian Zhang, Yan Wang, Wenbo Bu, Binbin Hou
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Abstract

Background: Evidence regarding the efficacy of surgery without postoperative adjuvant therapy (SWPAT) for dissecting cellulitis of the scalp (DCS) remains limited, and objective biomarkers predicting postoperative outcomes are lacking.

Objective: To describe clinical outcomes after SWPAT in a selected retrospective cohort and to explore the association between baseline IHS4 and recurrence.

Methods: Fifty-eight DCS patients were analyzed. Receiver operating characteristic (ROC) analysis identified the optimal baseline IHS4 cutoff for recurrence prediction. Recurrence-free survival (RFS) was assessed by Kaplan-Meier analysis, and multivariable Cox proportional hazards models were constructed using a two-covariate-per-model strategy to mitigate overfitting.

Results: SWPAT significantly improved IHS4, VAS, and DLQI scores (all p < 0.001). Baseline IHS4 predicted recurrence with an AUC of 0.823, yielding an optimal cutoff of 11.5. Patients were stratified into a low-risk group (LRG, IHS4 ≤ 11, n = 30) and a high-risk group (HRG, IHS4 ≥ 12, n = 28). Surgical approaches were balanced between groups (p = 0.869). The HRG showed significantly shorter RFS (log-rank p < 0.001), and HRG classification remained an independent predictor of recurrence after adjustment for disease duration.

Conclusions: SWPAT delivers sustained benefits in this selected cohort. Baseline IHS4 ≥ 12 predicts postoperative recurrence in DCS, requiring prospective external validation and do not establish comparative efficacy.

无术后辅助治疗的头皮夹层蜂窝织炎手术:一项选定队列的回顾性研究。
背景:关于无术后辅助治疗(SWPAT)的手术治疗头皮夹层蜂窝织炎(DCS)的有效性的证据仍然有限,并且缺乏预测术后预后的客观生物标志物。目的:在一个选定的回顾性队列中描述SWPAT后的临床结果,并探讨基线IHS4与复发之间的关系。方法:对58例DCS患者进行分析。受试者工作特征(ROC)分析确定了预测复发的最佳基线IHS4截止值。通过Kaplan-Meier分析评估无复发生存期(RFS),并采用双协变量/模型策略构建多变量Cox比例风险模型以减轻过拟合。结果:SWPAT显著改善了IHS4、VAS和DLQI评分(均p n = 30)和高危组(HRG, IHS4≥12,n = 28)。两组手术入路平衡(p = 0.869)。HRG显示了显著缩短的RFS (log-rank p)。结论:SWPAT在这个选定的队列中提供了持续的益处。基线IHS4≥12预测DCS术后复发,需要前瞻性外部验证,不能建立比较疗效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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