Regulation of follicular helper T cell subset differentiation in health and disease.

IF 4.2

Journal of molecular medicine (Berlin, Germany) Pub Date : 2026-09-29 DOI:10.1007/s00109-026-02721-6

Qing Xin, Longhao Zhao, Jinghe Zhang, Xinyi Liu, Guangwei Liu

{"title":"Regulation of follicular helper T cell subset differentiation in health and disease.","authors":"Qing Xin, Longhao Zhao, Jinghe Zhang, Xinyi Liu, Guangwei Liu","doi":"10.1007/s00109-026-02721-6","DOIUrl":null,"url":null,"abstract":"Follicular helper T (TFH) cells play a crucial role in adaptive humoral immunity. They provide help to B cells in the germinal centers (GCs), driving the affinity maturation of antigen-specific antibodies and class switch recombination. TFH cells possess profound heterogeneity in spatial distribution (e.g., GC-TFH, follicular mantle-TFH, circulating TFH, peripheral TFH) and phenotypic characteristics (e.g., TFH1, TFH2, TFH17), which enable TFH cells to respond to diverse immune challenges. This review summarizes the recent progress, including our data, on the TFH regulatory network driven by B-cell lymphoma 6 (Bcl-6) and cellular musculoaponeurotic fibrosarcoma oncogene homolog (c-Maf), and the contradictory roles exhibited by different TFH subsets under disparate pathological conditions such as viral infections, autoimmune diseases, and cancer. Integrating multiple TFH subsets into a systematic framework can provide a new perspective for understanding humoral immune regulation and developing new targeted therapies.","PeriodicalId":520678,"journal":{"name":"Journal of molecular medicine (Berlin, Germany)","volume":"104 1","pages":""},"PeriodicalIF":4.2000,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of molecular medicine (Berlin, Germany)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s00109-026-02721-6","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Follicular helper T (T_FH) cells play a crucial role in adaptive humoral immunity. They provide help to B cells in the germinal centers (GCs), driving the affinity maturation of antigen-specific antibodies and class switch recombination. T_FH cells possess profound heterogeneity in spatial distribution (e.g., GC-T_FH, follicular mantle-T_FH, circulating T_FH, peripheral T_FH) and phenotypic characteristics (e.g., T_FH1, T_FH2, T_FH17), which enable T_FH cells to respond to diverse immune challenges. This review summarizes the recent progress, including our data, on the T_FH regulatory network driven by B-cell lymphoma 6 (Bcl-6) and cellular musculoaponeurotic fibrosarcoma oncogene homolog (c-Maf), and the contradictory roles exhibited by different T_FH subsets under disparate pathological conditions such as viral infections, autoimmune diseases, and cancer. Integrating multiple T_FH subsets into a systematic framework can provide a new perspective for understanding humoral immune regulation and developing new targeted therapies.

查看原文本刊更多论文

滤泡辅助性T细胞亚群分化在健康和疾病中的调节。

滤泡辅助性T细胞（TFH）在适应性体液免疫中起重要作用。它们为生发中心（GCs）的B细胞提供帮助，推动抗原特异性抗体的亲和成熟和类开关重组。TFH细胞在空间分布（如GC-TFH、滤泡膜-TFH、循环TFH、外周TFH）和表型特征（如TFH1、TFH2、TFH17）上具有深刻的异质性，这使得TFH细胞能够应对多种免疫挑战。本文综述了b细胞淋巴瘤6 （Bcl-6）和细胞肌腱神经纤维肉瘤癌基因同源物（c-Maf）驱动的TFH调控网络的最新进展，包括我们的数据，以及不同TFH亚群在不同病理条件下（如病毒感染、自身免疫性疾病和癌症）所表现出的相互矛盾的作用。将多个TFH亚群整合到系统框架中可以为理解体液免疫调节和开发新的靶向治疗提供新的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of molecular medicine (Berlin, Germany)

自引率

0.00%

发文量