COVID-19 vaccination during pregnancy or lactation and infant growth and health care utilization.

IF 2.8 3区医学 Q1 PEDIATRICS

Academic Pediatrics Pub Date : 2026-09-28 DOI:10.1016/j.acap.2026.103477

Elyse O Kharbanda, Jingran Cao, Gabriela Vazquez-Benitez, Kirsten Ehresmann, Elisabeth M Seburg, Malini B DeSilva, Yihe G Daida, Kimberly K Vesco, Abbey Sidebottom, Rachel Effros, Heather S Lipkind, Kristin Palmsten

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引用次数: 0

Abstract

Objective: To evaluate associations between COVID-19 vaccination during pregnancy or lactation and infant growth and health care utilization.

Methods: This observational study from 4 U.S. health systems included singleton pregnancies with linked live births from December 2020-September 2022; eligibility varied by exposure and outcome. COVID-19 vaccinations were identified from electronic health records, claims, and immunization information systems. Infant health care utilization was based on number of outpatient (OP) or emergency department (ED) visits while faltering weight was identified from weight-for-length percentiles. Outcomes were compared for those with and without COVID-19 vaccine exposures ≥20 weeks gestation or during lactation and within 90 days following delivery. For OP and ED visits, we calculated adjusted rate ratio (aRR) and 95% confidence intervals (CI) using negative binomial regression. For faltering weight, we calculated adjusted prevalence ratio (aPR) and 95% CIs using Poisson regression.

Results: Among 7,141 eligible mother-infant dyads, aRRs for infant OP and ED visits by 6 months following COVID-19 vaccination during pregnancy were 1.03 (95% CI 0.99-1.06) and 1.03 (0.83-1.27), respectively. Among 11,921 eligible mother-infant dyads the aPR for faltering weight by 12 months following vaccination during pregnancy was 1.07 (0.89-1.28). Among 8,442 lactating mother-infant dyads, aRRs for infant OP and ED visits within 90 days of postpartum vaccination were 1.03 (0.98-1.08) and 1.05 (0.70-1.56), respectively. Among 10,181 mother-infant dyads, the aPR for faltering weight following vaccination during lactation was 0.62 (0.48-0.79).

Conclusion: COVID-19 vaccination during pregnancy or lactation was not associated with adverse infant growth or health care utilization.

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妊娠或哺乳期COVID-19疫苗接种以及婴儿生长和保健利用。

目的：评价妊娠或哺乳期接种COVID-19疫苗与婴儿生长发育和保健利用的关系。方法：这项来自美国4个卫生系统的观察性研究包括2020年12月至2022年9月期间伴有相关活产的单胎妊娠；资格因暴露和结果而异。从电子健康记录、索赔和免疫信息系统中确定了COVID-19疫苗接种。婴儿保健利用是基于门诊（OP）或急诊（ED）访问的次数，而体重不稳是根据体重长度百分位数确定的。比较妊娠≥20周或哺乳期和分娩后90天内接触和未接触COVID-19疫苗的患者的结局。对于OP和ED就诊，我们使用负二项回归计算调整率比（aRR）和95%置信区间（CI）。对于体重不稳，我们使用泊松回归计算调整患病率（aPR）和95% ci。结果：在7141对符合条件的母婴中，妊娠期接种COVID-19疫苗后6个月婴儿OP和ED就诊的arr分别为1.03 （95% CI 0.99-1.06）和1.03（0.83-1.27）。在11921名符合条件的母婴中，妊娠期接种疫苗后12个月体重下降的aPR为1.07（0.89-1.28）。在8442对哺乳期母婴中，接种疫苗后90天内婴幼儿OP和ED就诊的arr分别为1.03（0.98-1.08）和1.05（0.70-1.56）。在10,181对母婴中，哺乳期间接种疫苗后体重下降的aPR为0.62（0.48-0.79）。结论：妊娠期或哺乳期接种COVID-19疫苗与婴儿生长不良或医疗保健利用无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Academic Pediatrics PEDIATRICS-

CiteScore

4.60

自引率

12.90%

发文量

300

审稿时长

60 days

期刊介绍： Academic Pediatrics, the official journal of the Academic Pediatric Association, is a peer-reviewed publication whose purpose is to strengthen the research and educational base of academic general pediatrics. The journal provides leadership in pediatric education, research, patient care and advocacy. Content areas include pediatric education, emergency medicine, injury, abuse, behavioral pediatrics, holistic medicine, child health services and health policy,and the environment. The journal provides an active forum for the presentation of pediatric educational research in diverse settings, involving medical students, residents, fellows, and practicing professionals. The journal also emphasizes important research relating to the quality of child health care, health care policy, and the organization of child health services. It also includes systematic reviews of primary care interventions and important methodologic papers to aid research in child health and education.