Recent Progress in Catalytic Asymmetric Pictet-Spengler Reaction to Construct 1,1-Disubstituted Scaffolds.

IF 2.2 4区化学 Q2 CHEMISTRY, ORGANIC

Synthesis-Stuttgart Pub Date : 2026-05-01 Epub Date: 2026-01-23 DOI:10.1055/a-2779-3222

Ruiying Jiang, Hans Renata

引用次数: 0

Abstract

1,1-disubstituted tetrahydroisoquinolines (THIQs) and tetrahydro-β-carbolines (THBCs) are key intermediates in the synthesis of various alkaloid natural products. These 1,1-disubstituted scaffolds are typically constructed via the Pictet-Spengler reaction. The asymmetric catalytic variant of this reaction enables access to stereochemically pure compounds with significant biological properties. This review focuses on recent progress in organocatalyzed and enzyme-catalyzed asymmetric Pictet-Spengler reactions to generate these 1,1-disubstituted motifs.

查看原文本刊更多论文

催化不对称Pictet-Spengler反应制备1,1-二取代支架的研究进展。

1,1-二取代四氢异喹啉（THIQs）和四氢β-碳碱（thbc）是合成各种生物碱天然产物的关键中间体。这些1,1-二取代支架通常是通过Pictet-Spengler反应构建的。该反应的不对称催化变体可以获得具有重要生物特性的立体化学纯化合物。本文综述了有机催化和酶催化的不对称Pictet-Spengler反应制备1,1-二取代基序的最新进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Synthesis-Stuttgart 化学-有机化学

CiteScore

4.50

自引率

7.70%

发文量

435

审稿时长

1 months

期刊介绍： SYNTHESIS is an international full-paper journal devoted to the advancement of the science of chemical synthesis. It covers all fields of organic chemistry involving synthesis, including catalysis, organometallic, medicinal, biological, and photochemistry, but also related disciplines. SYNTHESIS provides dependable research results with detailed and reliable experimental procedures and full characterization of all important new products as well as scientific primary data.