Metabolites and cancer metastasis

IF 9.1 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Oncogene Pub Date : 2026-09-27 DOI:10.1038/s41388-026-03930-6

Suisui Yang, Silin Shi, Junchen Hou, Jian Zhang, Zhenyi Su

引用次数: 0

Abstract

Over the past decades, metastasis research has largely emphasized genetic and epigenetic regulators. Emerging evidence indicates that metabolites—including sugars (glucose, fructose), antioxidant vitamins, glutathione, lipids (palmitic acid, cholesterol), and amino acids (glutamine, aspartate, BCAAs)—can critically influence metastasis in a context-dependent manner by driving or restraining progression via metabolic reprogramming and signaling modulation. This review examines how cancer cells re-modulate core metabolic pathways to adapt and metastasize, summarizes how endogenous metabolites, dietary bioactive compounds, metabolic toxins, and pharmacological agents regulate metastasis, and discusses new concepts and perspectives on metabolic regulation of tumor metastasis, and outlines future directions in metabolite-driven tumor metastasis. The metabolic dependencies of metastasis provide a rational basis for intervention through integrated nutritional and therapeutic strategies.

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代谢物和癌症转移。

在过去的几十年里，转移研究主要强调遗传和表观遗传调控因子。新出现的证据表明，代谢物——包括糖（葡萄糖、果糖）、抗氧化维生素、谷胱甘肽、脂质（棕榈酸、胆固醇）和氨基酸（谷氨酰胺、天冬氨酸、支链氨基酸）——可以通过代谢重编程和信号调节驱动或抑制转移，以一种依赖于环境的方式对转移产生关键影响。本文综述了肿瘤细胞如何重新调节核心代谢途径以适应和转移，总结了内源性代谢物、膳食生物活性化合物、代谢性毒素和药物对肿瘤转移的调节作用，讨论了代谢调节肿瘤转移的新概念和新观点，并展望了代谢物驱动的肿瘤转移的未来发展方向。转移的代谢依赖性为通过综合营养和治疗策略进行干预提供了合理的基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oncogene 医学-生化与分子生物学

CiteScore

15.30

自引率

1.20%

发文量

404

审稿时长

1 months

期刊介绍： Oncogene is dedicated to advancing our understanding of cancer processes through the publication of exceptional research. The journal seeks to disseminate work that challenges conventional theories and contributes to establishing new paradigms in the etio-pathogenesis, diagnosis, treatment, or prevention of cancers. Emphasis is placed on research shedding light on processes driving metastatic spread and providing crucial insights into cancer biology beyond existing knowledge. Areas covered include the cellular and molecular biology of cancer, resistance to cancer therapies, and the development of improved approaches to enhance survival. Oncogene spans the spectrum of cancer biology, from fundamental and theoretical work to translational, applied, and clinical research, including early and late Phase clinical trials, particularly those with biologic and translational endpoints.