Light-Emitting Diode–Activated Gel Fluorescent Light Energy Therapy as Maintenance Treatment Following Aminolevulinic Acid Photodynamic Therapy for Severe Acne: A Case Report

IF 1 4区医学 Q1 DERMATOLOGY

Dermatologic Therapy Pub Date : 2026-09-21 DOI:10.1155/dth/2771827

Wenjiang Qian, Hongyi Zhao, Rongxin Ren

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Abstract

Severe acne frequently relapses after aminolevulinic acid photodynamic therapy (ALA-PDT), and adverse reactions such as erythema and dryness may limit tolerability. We report a 24-year-old woman with Grade IV acne treated with two ALA-PDT sessions followed by light-emitting diode–activated gel fluorescent light energy (FLE) therapy as posttreatment maintenance. FLE was applied twice weekly for six weeks. Compared with the discomfort of ALA-PDT (VAS: 7), FLE was painless (VAS: 0) and well tolerated during the maintenance phase. At 1 month after completion of the combined regimen, lesions continued to resolve with decreased erythema and porphyrin fluorescence on VISIA imaging, without relapse or adverse events. At 3- and 12-month follow-ups, clinical improvement was maintained, with progressive improvements in lesion counts and skin quality. This case illustrates the feasibility of incorporating FLE as a maintenance approach following ALA-PDT and highlights its potential clinical value in the management of severe acne.

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发光二极管活化凝胶荧光光能疗法作为氨基乙酰丙酸光动力疗法后维持治疗重度痤疮1例报告

严重的痤疮在氨基乙酰丙酸光动力治疗（ALA-PDT）后经常复发，并且诸如红斑和干燥等不良反应可能限制耐受性。我们报告了一名24岁的IV级痤疮女性，接受了两次ALA-PDT治疗，随后进行了发光二极管激活凝胶荧光光能（FLE）治疗作为治疗后维持。FLE每周应用两次，持续六周。与ALA-PDT的不适感（VAS: 7）相比，FLE在维持期无痛（VAS: 0）且耐受性良好。在联合治疗方案完成1个月后，病变继续消退，VISIA成像显示红斑和卟啉荧光减少，无复发或不良事件。在3个月和12个月的随访中，临床改善保持不变，病变计数和皮肤质量渐进式改善。本病例说明了将FLE作为ALA-PDT后的维持方法的可行性，并强调了其在治疗严重痤疮中的潜在临床价值。

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来源期刊

Dermatologic Therapy 医学-皮肤病学

CiteScore

7.00

自引率

8.30%

发文量

711

审稿时长

3 months

期刊介绍： Dermatologic Therapy has been created to fill an important void in the dermatologic literature: the lack of a readily available source of up-to-date information on the treatment of specific cutaneous diseases and the practical application of specific treatment modalities. Each issue of the journal consists of a series of scholarly review articles written by leaders in dermatology in which they describe, in very specific terms, how they treat particular cutaneous diseases and how they use specific therapeutic agents. The information contained in each issue is so practical and detailed that the reader should be able to directly apply various treatment approaches to daily clinical situations. Because of the specific and practical nature of this publication, Dermatologic Therapy not only serves as a readily available resource for the day-to-day treatment of patients, but also as an evolving therapeutic textbook for the treatment of dermatologic diseases.