Sheila I. de Diego Saadia, Sergio H. Szajnman, Juan B. Rodriguez
{"title":"An updated review of enantioselective syntheses and biological actions of carbanucleosides","authors":"Sheila I. de Diego Saadia, Sergio H. Szajnman, Juan B. Rodriguez","doi":"10.1007/s00044-026-03623-5","DOIUrl":null,"url":null,"abstract":"<div><p>Carbocyclic nucleosides are nucleoside analogues where the oxygen atom of the furanose ring is replaced by a methylene group, in many cases a substituted methylene moiety, giving rise to metabolically stable nucleosides analogues that are recognized by the same enzymes that interact with canonical nucleosides. In this article, we were focused on the relevant features of the chemistry and biological properties of this family of compounds emphasizing synthetic aspects to access carbocyclic nucleosides enantioselectively and a comprehensive panorama of their biological properties. Molecular recognition outlook of enzymes of pharmacological importance are discussed. The influence of sugar conformation and puckering in modulating the biological activity and the use of carbanucleosides are illustrated.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":699,"journal":{"name":"Medicinal Chemistry Research","volume":"35 10","pages":"1975 - 2006"},"PeriodicalIF":3.5000,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medicinal Chemistry Research","FirstCategoryId":"3","ListUrlMain":"https://link.springer.com/article/10.1007/s00044-026-03623-5","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
Carbocyclic nucleosides are nucleoside analogues where the oxygen atom of the furanose ring is replaced by a methylene group, in many cases a substituted methylene moiety, giving rise to metabolically stable nucleosides analogues that are recognized by the same enzymes that interact with canonical nucleosides. In this article, we were focused on the relevant features of the chemistry and biological properties of this family of compounds emphasizing synthetic aspects to access carbocyclic nucleosides enantioselectively and a comprehensive panorama of their biological properties. Molecular recognition outlook of enzymes of pharmacological importance are discussed. The influence of sugar conformation and puckering in modulating the biological activity and the use of carbanucleosides are illustrated.
期刊介绍：
Medicinal Chemistry Research (MCRE) publishes papers on a wide range of topics, favoring research with significant, new, and up-to-date information. Although the journal has a demanding peer review process, MCRE still boasts rapid publication, due in part, to the length of the submissions. The journal publishes significant research on various topics, many of which emphasize the structure-activity relationships of molecular biology.
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