MRI contrast agents toward cancer treatment: progress and perspectives

IF 2 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

International Journal of Mechanical and Materials Engineering Pub Date : 2026-07-02 Epub Date: 2026-09-23 DOI:10.1186/s40712-026-00517-7

Fang Wang, Changye Zheng, Bihua Liu, Jiahao Wu, Xianxing Zhou, Zhenghua Tang, Lihua Xiao, Manqiu Liang, Bingchen Zhang, Yujian Zou

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Abstract

Magnetic resonance imaging (MRI) is a leading non-invasive imaging modality with high resolution and deep tissue penetration, and it has been widely used in clinical and preclinical cancer diagnosis and therapy. MRI contrast agents play an indispensable role in improving the imaging sensitivity and the contrast effect. This review first outlines the clinical significance of developing high-performance MRI contrast agents for cancer treatment, and summarizes the recent advances in four major categories: gadolinium (Gd)-based contrast agents, magnetic metal oxide nanomaterials, biomolecules-based contrast agents, and hybrid nanocomposites. Representative studies are selected to illustrate the structure-performance relationships at molecule level. The current challenges and future perspectives in this field are also critically discussed. This review is expected to stimulate further research efforts and promote the clinical translation of advanced MRI contrast agents for cancer theranostics.

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MRI造影剂在癌症治疗中的应用：进展与展望

磁共振成像（MRI）是一种具有高分辨率、深穿透性的无创成像技术，已广泛应用于临床和临床前肿瘤的诊断和治疗。MRI造影剂在提高成像灵敏度和造影剂效果方面发挥着不可或缺的作用。本文首先概述了开发高性能MRI造影剂用于癌症治疗的临床意义，并总结了钆基造影剂、磁性金属氧化物纳米材料、生物分子基造影剂和混合纳米复合材料四大类造影剂的最新进展。本文选取具有代表性的研究来说明分子水平上的结构-性能关系。在这个领域当前的挑战和未来的前景也进行了批判性的讨论。这篇综述有望激发进一步的研究努力，并促进先进的MRI造影剂在癌症治疗中的临床应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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